tert-butyl N-[(1S,2R)-1-benzyl-3-(1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl)-2-hydroxypropyl]carbamate

Base Information

Chemical Name:tert-butyl N-[(1S,2R)-1-benzyl-3-(1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl)-2-hydroxypropyl]carbamate
CAS No.:1301767-82-7
Molecular Formula:C₂₄H₃₂N₂O₅S
Molecular Weight:460.594
Hs Code.:

Synonyms:tert-butyl N-[(1S,2R)-1-benzyl-3-(1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl)-2-hydroxypropyl]carbamate

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Chemical Property of tert-butyl N-[(1S,2R)-1-benzyl-3-(1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl)-2-hydroxypropyl]carbamate

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Technology Process of tert-butyl N-[(1S,2R)-1-benzyl-3-(1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl)-2-hydroxypropyl]carbamate

There total 3 articles about tert-butyl N-[(1S,2R)-1-benzyl-3-(1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl)-2-hydroxypropyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1337570-31-6
2,3,4,5-tetrahydro-1H-1λ6,2-benzothiazepine-1,1-dione

: 98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

: 1301767-82-7
tert-butyl N-[(1S,2R)-1-benzyl-3-(1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl)-2-hydroxypropyl]carbamate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm200778q

Reference yield:

: 2905-25-1
o-bromobenzenesulfonyl chloride

: 1301767-82-7
tert-butyl N-[(1S,2R)-1-benzyl-3-(1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl)-2-hydroxypropyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 20 °C / Inert atmosphere

2: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 60 - 110 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With pyridine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; caesium carbonate; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm200778q

Reference yield:

: 851297-52-4
N-allyl-2-bromobenzenesulfonamide

: 1301767-82-7
tert-butyl N-[(1S,2R)-1-benzyl-3-(1,1-dioxo-1,3,4,5-tetrahydro-2H-1λ6,2-benzothiazepin-2-yl)-2-hydroxypropyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 60 - 110 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; caesium carbonate; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm200778q