[(S)-fluoro{hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl}methyl]phosphonic acid

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Chemical Name:[(S)-fluoro{hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl}methyl]phosphonic acid
CAS No.:1375082-89-5
Molecular Formula:C₁₃H₁₈FNO₈P₂
Molecular Weight:397.234
Hs Code.:

Synonyms:[(S)-fluoro{hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl}methyl]phosphonic acid

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Chemical Property of [(S)-fluoro{hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl}methyl]phosphonic acid

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Technology Process of [(S)-fluoro{hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl}methyl]phosphonic acid

There total 7 articles about [(S)-fluoro{hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl}methyl]phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: (x)C₆H₁₅N*C₁₇H₂₅FN₂O₈P₂

: 1375082-89-5
[(S)-fluoro{hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl}methyl]phosphonic acid

Guidance literature:: (x)C₆H₁₅N*C₁₇H₂₅FN₂O₈P₂; In water; at 20 ℃;

With hydrogenchloride; In water;
DOI:10.1021/ja300218x

Reference yield:

: 1375082-72-6
methyl (7S)-7-phenyl-4-fluoro-3,5-dimethoxy-2,6-dioxa-3,5-diphosphaoctan-8-oate-3,5-dioxide

: 1375082-89-5
[(S)-fluoro{hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl}methyl]phosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: trimethylsilyl bromide / acetonitrile / 20 °C

1.2: 0.25 h / 20 °C

2.1: water; sodium carbonate / pH 8

3.1: water; tert-butyl alcohol / 20 °C

3.2: Reflux

3.3: pH 7.4

4.1: cation exchange Dowex resin / water / 20 °C

With trimethylsilyl bromide; water; sodium carbonate; In water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ja300218x

Reference yield:

: methyl (2S)-({[fluoro(phosphono)methyl](hydroxy)phosphoryl}oxy)(phenyl)ethanoate

: 1375082-89-5
[(S)-fluoro{hydroxy[(1S)-2-(morpholin-4-yl)-2-oxo-1-phenylethoxy]phosphoryl}methyl]phosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium carbonate / pH 8

2.1: water; tert-butyl alcohol / 20 °C

2.2: Reflux

2.3: pH 7.4

3.1: cation exchange Dowex resin / water / 20 °C

With water; sodium carbonate; In water; tert-butyl alcohol;
DOI:10.1021/ja300218x