2-(allyl(benzyl)amino)-6-((tert-butyldimethylsilyl)oxy)hexanenitrile

Base Information

• Chemical Name: 2-(allyl(benzyl)amino)-6-((tert-butyldimethylsilyl)oxy)hexanenitrile
• CAS No.: 1437872-65-5
• Molecular Formula: C₂₂H₃₆N₂OSi
• Molecular Weight: 372.626
• Mol file: 1437872-65-5.mol

Synonyms:2-(allyl(benzyl)amino)-6-((tert-butyldimethylsilyl)oxy)hexanenitrile

Chemical Property of 2-(allyl(benzyl)amino)-6-((tert-butyldimethylsilyl)oxy)hexanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(allyl(benzyl)amino)-6-((tert-butyldimethylsilyl)oxy)hexanenitrile

There total 2 articles about 2-(allyl(benzyl)amino)-6-((tert-butyldimethylsilyl)oxy)hexanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H30N2OSi + benzyl bromide (100-39-0) → 2-(allyl(benzyl)amino)-6-((tert-butyldimethylsilyl)oxy)hexanenitrile (1437872-65-5)

Guidance literature:

With 15-crown-5; sodium fluoride; In benzene; at 90 ℃; for 10h; Schlenk technique; Glovebox;

DOI:10.1016/j.bmcl.2013.03.114

Reference yield:

C14H29NOSi → 2-(allyl(benzyl)amino)-6-((tert-butyldimethylsilyl)oxy)hexanenitrile (1437872-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 3 h / 20 °C / Schlenk technique; Glovebox; Inert atmosphere

2: sodium fluoride; 15-crown-5 / benzene / 10 h / 90 °C / Schlenk technique; Glovebox

With 15-crown-5; sodium fluoride; In benzene;

DOI:10.1016/j.bmcl.2013.03.114

Reference yield: 92.0%

2-(allyl(benzyl)amino)-6-((tert-butyldimethylsilyl)oxy)hexanenitrile (1437872-65-5) → N2-allyl-N2-benzyl-6-((tert-butyldimethylsilyl)oxy)hexane-1,2-diamine (1437872-67-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 7h; Schlenk technique; Glovebox; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.03.114

upstream raw materials:

benzyl bromide

Downstream raw materials:

N²-allyl-N²-benzyl-6-((tert-butyldimethylsilyl)oxy)hexane-1,2-diamine