(Z)-1-(1,1-DiMethyl-2-heptenyl)-3-(phenylMethoxy)benzene

Base Information

• Chemical Name: (Z)-1-(1,1-DiMethyl-2-heptenyl)-3-(phenylMethoxy)benzene
• CAS No.: 70120-10-4
• Molecular Formula: C₂₂H₂₈O
• Molecular Weight: 308.464
• Mol file: 70120-10-4.mol

Synonyms:1-(benzyloxy)-3-(1,1-dimethyl-2-heptenyl)benzene

Chemical Property of (Z)-1-(1,1-DiMethyl-2-heptenyl)-3-(phenylMethoxy)benzene

Chemical Property:

• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

(Z)-1-(1,1-Dimethyl-2-heptenyl)-3-(benzyloxy)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Intermediate in the synthesis of 3-[2-Hydroxy-4-(substituted) phenyl]azacycloalkanes as analgesic agents.

Technology Process of (Z)-1-(1,1-DiMethyl-2-heptenyl)-3-(phenylMethoxy)benzene

There total 3 articles about (Z)-1-(1,1-DiMethyl-2-heptenyl)-3-(phenylMethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-(3-benzyloxyphenyl)-2-methylpropionaldehyde (70120-09-1) + pentyltriphenylphosphonium bromide (21406-61-1) → 1-(benzyloxy)-3-(1,1-dimethyl-2-heptenyl)benzene (70120-10-4)

Guidance literature:

With sodium hydroxide; dimethyl sulfoxide; at 15 ℃; for 4h;

DOI:10.1021/jm00367a013

Reference yield:

2-<3-(benzyloxy)phenyl>-2-methylpropionitrile (70120-08-0) → 1-(benzyloxy)-3-(1,1-dimethyl-2-heptenyl)benzene (70120-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) diisobutylaluminium hydride (DIBAL), 2.) aq. H₂SO₄ / 1.) THF, hexane, 25 deg C, 2 h, 2.) THF, hexane, 25 deg C, 2 h

2: 57 percent / DMSO, NaOH / 4 h / 15 °C

With sodium hydroxide; sulfuric acid; diisobutylaluminium hydride; dimethyl sulfoxide;

DOI:10.1021/jm00367a013

Reference yield:

→ 1-(benzyloxy)-3-(1,1-dimethyl-2-heptenyl)benzene (70120-10-4)

Guidance literature:

Verb. /BRN= 697154/, Ph3P=CH(CH2)3CH3;

upstream raw materials:

2-(3-benzyloxyphenyl)-2-methylpropionaldehyde

pentyltriphenylphosphonium bromide

2-<3-(benzyloxy)phenyl>-2-methylpropionitrile

Downstream raw materials:

1-bromo-2-benzyloxy-4-(1,1-dimethylheptyl)benzene

4-<4-(1,1-dimethylheptyl)-2-hydroxyphenyl>-2-pentanone

3-<4-(1,1-dimethylheptyl)-2-hydroxyphenyl>cyclohexanone

4-<2-(benzyloxy)-4-(1,1-dimethylheptyl)phenyl>-2-pentanol

Refernces