70120-08-0

Basic information

• Product Name: α,α-diMethyl-3-(phenylMethoxy)benzeneacetonitrile
• Synonyms: 2-[3-(Benzyloxy)phenyl]-2-Methylpropionitrile;α,α-diMethyl-3-(phenylMethoxy)benzeneacetonitrile
• CAS NO: 70120-08-0
• Molecular Formula: C₁₇H₁₇NO
• Molecular Weight: 251.32298
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 70120-08-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: α,α-diMethyl-3-(phenylMethoxy)benzeneacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: α,α-diMethyl-3-(phenylMethoxy)benzeneacetonitrile(70120-08-0)
• EPA Substance Registry System: α,α-diMethyl-3-(phenylMethoxy)benzeneacetonitrile(70120-08-0)

Safety Data

• Hazardous Substances Data: 70120-08-0(Hazardous Substances Data)

Usage

Chemical Properties

Orange Solid

Uses

α,α-diMethyl-3-(phenylMethoxy)benzeneacetonitrile is a reagent used in the preparation of BACE inhibitors and protein kinase C ligands.

Upstream product

• 74-83-9 methyl bromide 
• 20967-96-8 2-(3-benzyloxyphenyl)acetonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 628330-14-3 2-(3-benzyloxyphenyl)-2-methylpropanoic acid 
• 628330-15-4 methyl 2-(3-benzyloxyphenyl)-2-methylpropanoate 
• 628334-51-0 ethyl 3-[4-(3-{3-ethoxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-3-hydroxyphenyl]propanoate 
• 149490-75-5 2-(3-hydroxy-phenyl)-2-methyl-propionic acid methyl ester 
• 70434-49-0 (Z)-3-<2-(benzyloxy)-4-(1,1-dimethylheptyl)phenyl>cyclohexanol 
• 70434-50-3 (E)-3-<2-(benzyloxy)-4-(1,1-dimethylheptyl)phenyl>cyclohexanol 
• 70434-82-1 (Z)-3-<4-(1,1-dimethylheptyl)-2-hydroxyphenyl>cyclohexanol 
• 70434-83-2 (E)-3-<4-(1,1-dimethylheptyl)-2-hydroxyphenyl>cyclohexanol 
• 70119-97-0 4-<2-(benzyloxy)-4-(1,1-dimethylheptyl)phenyl>-2-pentanone 
• 70120-10-4 1-(benzyloxy)-3-(1,1-dimethyl-2-heptenyl)benzene 
• 70120-03-5 4-<4-(1,1-dimethylheptyl)-2-hydroxyphenyl>-2-pentanol 
• 70434-13-8 3-<2-(benzyloxy)-4-(1,1-dimethylheptyl)phenyl>cyclohexanone 
• 70120-01-3 4-<2-(benzyloxy)-4-(1,1-dimethylheptyl)phenyl>-2-pentanol 

Relevant articles and documents

NOVEL DIHYDROPYRIDOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS

A compound according to Formula I: wherein R1, LA, GA, R2a, R2b, R3, R4, R5, and R6 are as described herein. The present invention relates to novel compound

Phenyl derivatives and methods of use

Novel phenyl compounds, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the compounds are agonists and/or ligands of cannabinoid receptors and may be useful, inter alia, for treating and/or preventing pain, gastrointestinal disorders, genitourinary disorders, inflammation, glaucoma, auto-immune diseases, ischemic conditions, immune-related disorders, and neurodegenerative diseases, for providing cardioprotection against ischemic and reperfusion effects, for inducing apoptosis in malignant cells, and as an appetite stimulant.

A Cannabinoid Derived Prototypical Analgesic

The synthesis and analgesic testing of 3-cyclohexanol (1) are described.Prior (SAR) studies led us to conclude that the pyran ring of 9-nor-9β-hydroxyhexahydrocannabinol (HHC) was not necessary for the expression of biological activity in this series of cannabinoids.Analysis of models and the use of molecular mechanics calculations suggested that a simpler compound, such as 1, would possess the biological activity of HHC.Compound 1 was prepared in nine steps from acetonitrile (2).Biological testing in five models of pain shows that compound 1 and morphine are equally potent as analgesics and demonstrates that the pyran ring of HHC is not necessary for biological activity.Further simplification of 1 was pursued by the synthesis of 4--2-pentanol (17), but this derivative exhibits significantly reduced analgesic activity.