2-benzyloxycarbonylamino-N-(5-chloro-2-phenylcarbamoylacetyl-phenyl)-malonamic acid ethyl ester

Base Information

• Chemical Name: 2-benzyloxycarbonylamino-N-(5-chloro-2-phenylcarbamoylacetyl-phenyl)-malonamic acid ethyl ester
• CAS No.: 350238-04-9
• Molecular Formula: C₂₈H₂₆ClN₃O₇
• Molecular Weight: 551.983

Synonyms:2-benzyloxycarbonylamino-N-(5-chloro-2-phenylcarbamoylacetyl-phenyl)-malonamic acid ethyl ester

Chemical Property of 2-benzyloxycarbonylamino-N-(5-chloro-2-phenylcarbamoylacetyl-phenyl)-malonamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyloxycarbonylamino-N-(5-chloro-2-phenylcarbamoylacetyl-phenyl)-malonamic acid ethyl ester

There total 5 articles about 2-benzyloxycarbonylamino-N-(5-chloro-2-phenylcarbamoylacetyl-phenyl)-malonamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Nα-(carbobenzyloxy)-α-carbethoxyglycine (7682-49-7) + 3-(2-amino-4-chloro-phenyl)-3-oxo-N-phenyl-propionamide (350237-98-8) → 2-benzyloxycarbonylamino-N-(5-chloro-2-phenylcarbamoylacetyl-phenyl)-malonamic acid ethyl ester (350238-04-9)

Guidance literature:

With pyridine; phosphorus pentachloride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(01)00402-6

Reference yield:

4-chloro-2-nitro-benzoic acid (6280-88-2) → 2-benzyloxycarbonylamino-N-(5-chloro-2-phenylcarbamoylacetyl-phenyl)-malonamic acid ethyl ester (350238-04-9)

Guidance literature:

Multi-step reaction with 5 steps

1: SOCl₂

2: MgCl₂; Et₃N / acetonitrile

3: 85 percent / xylene / Heating

4: 97 percent / Fe; CaCl₂ / ethanol

5: 74 percent / PCl₅; pyridine / tetrahydrofuran

With pyridine; thionyl chloride; phosphorus pentachloride; iron; triethylamine; calcium chloride; magnesium chloride; In tetrahydrofuran; ethanol; acetonitrile; xylene;

DOI:10.1016/S0040-4039(01)00402-6

Reference yield:

4-chloro-2-nitro-benzoyl chloride (41995-04-4) → 2-benzyloxycarbonylamino-N-(5-chloro-2-phenylcarbamoylacetyl-phenyl)-malonamic acid ethyl ester (350238-04-9)

Guidance literature:

Multi-step reaction with 4 steps

1: MgCl₂; Et₃N / acetonitrile

2: 85 percent / xylene / Heating

3: 97 percent / Fe; CaCl₂ / ethanol

4: 74 percent / PCl₅; pyridine / tetrahydrofuran

With pyridine; phosphorus pentachloride; iron; triethylamine; calcium chloride; magnesium chloride; In tetrahydrofuran; ethanol; acetonitrile; xylene;

DOI:10.1016/S0040-4039(01)00402-6

upstream raw materials:

N^α-(carbobenzyloxy)-α-carbethoxyglycine

3-(2-amino-4-chloro-phenyl)-3-oxo-N-phenyl-propionamide

4-chloro-2-nitro-benzoic acid

4-chloro-2-nitro-benzoyl chloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 350238-04-9 2-benzyloxycarbonylamino-N-(5-chloro-2-phenylcarbamoylacetyl-phenyl)-malonamic acid ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send