(R)-7-methyl-N-(2-methyl-5-(5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:(R)-7-methyl-N-(2-methyl-5-(5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1426667-50-6
Molecular Formula:C₂₃H₂₂F₃N₅O₃
Molecular Weight:473.455
Hs Code.:

Synonyms:(R)-7-methyl-N-(2-methyl-5-(5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of (R)-7-methyl-N-(2-methyl-5-(5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of (R)-7-methyl-N-(2-methyl-5-(5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

There total 10 articles about (R)-7-methyl-N-(2-methyl-5-(5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21801-80-9
7-methylimidazo[1,2-a]pyridine-3-carboxylic acid

: 1426671-52-4
(R)-4-[3-(3-amino-4-methylphenyl)-1,2,4-oxadiazol-5-yl]-1,1,1-trifluoro-2-methylbutan-2-ol

: 1426667-50-6
(R)-7-methyl-N-(2-methyl-5-(5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: 7-methylimidazo[1,2-a]pyridine-3-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

(R)-4-[3-(3-amino-4-methylphenyl)-1,2,4-oxadiazol-5-yl]-1,1,1-trifluoro-2-methylbutan-2-ol; With pyridine; at 20 ℃; for 0.333333h;

Reference yield:

: 123-76-2
levulinic acid

: 1426667-50-6
(R)-7-methyl-N-(2-methyl-5-(5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

1.2: 0.75 h / 125 °C

2.1: N,N-dimethyl-formamide / dichloromethane-d2 / 0.5 h / 20 °C

2.2: 0.33 h / 20 °C

3.1: tetrabutyl ammonium fluoride; (trifluoromethyl)trimethylsilane / tetrahydrofuran / 1 h / -20 - 20 °C

4.1: Chiralpak IC 20 μm column / Resolution of racemate

With tetrabutyl ammonium fluoride; (trifluoromethyl)trimethylsilane; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane-d2;

Reference yield:

: 1426671-14-8
3-amino-N-hydroxy-4-methylbenzimidamide

: 1426667-50-6
(R)-7-methyl-N-(2-methyl-5-(5-(4,4,4-trifluoro-3-hydroxy-3-methylbutyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

1.2: 0.75 h / 125 °C

2.1: N,N-dimethyl-formamide / dichloromethane-d2 / 0.5 h / 20 °C

2.2: 0.33 h / 20 °C

3.1: tetrabutyl ammonium fluoride; (trifluoromethyl)trimethylsilane / tetrahydrofuran / 1 h / -20 - 20 °C

4.1: Chiralpak IC 20 μm column / Resolution of racemate

With tetrabutyl ammonium fluoride; (trifluoromethyl)trimethylsilane; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane-d2;