3-cyclohexyl-N-[2-(5-fluoro-2,3-dihydro-indol-1-yl)-1-methyl-ethyl]-2-hydroxy-propionamide

Base Information

Chemical Name:3-cyclohexyl-N-[2-(5-fluoro-2,3-dihydro-indol-1-yl)-1-methyl-ethyl]-2-hydroxy-propionamide
CAS No.:913179-35-8
Molecular Formula:C₂₀H₂₉FN₂O₂
Molecular Weight:348.461
Hs Code.:

3-cyclohexyl-<i>N</i>-[2-(5-fluoro-2,3-dihydro-indol-1-yl)-1-methyl-ethyl]-2-hydroxy-propionamide

Synonyms:3-cyclohexyl-N-[2-(5-fluoro-2,3-dihydro-indol-1-yl)-1-methyl-ethyl]-2-hydroxy-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-cyclohexyl-N-[2-(5-fluoro-2,3-dihydro-indol-1-yl)-1-methyl-ethyl]-2-hydroxy-propionamide

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Technology Process of 3-cyclohexyl-N-[2-(5-fluoro-2,3-dihydro-indol-1-yl)-1-methyl-ethyl]-2-hydroxy-propionamide

There total 2 articles about 3-cyclohexyl-N-[2-(5-fluoro-2,3-dihydro-indol-1-yl)-1-methyl-ethyl]-2-hydroxy-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 259858-32-7
(S)-2-(5-fluoro-2,3-dihydro-indol-1-yl)-1-methyl-ethylamine

: 62377-41-7
(S)-3-cyclohexyl-2-hydroxypropionic acid

: 913179-35-8
3-cyclohexyl-N-[2-(5-fluoro-2,3-dihydro-indol-1-yl)-1-methyl-ethyl]-2-hydroxy-propionamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane;
DOI:10.1016/j.bmcl.2006.07.032

Reference yield:

: 20312-36-1
L-3-phenyllactic acid

: 913179-35-8
3-cyclohexyl-N-[2-(5-fluoro-2,3-dihydro-indol-1-yl)-1-methyl-ethyl]-2-hydroxy-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / H₂ / Rh/C / ethanol; H₂O / 18 h / 50 °C / 51714.8 Torr

2: 57 percent / HATU; DIEA / CH₂Cl₂

With hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; Rh on carbon; In ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2006.07.032