6-tert-Butyl-2-[3-(5-{5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-2-hydroxymethylphenyl]-8-fluoro-2H-phthalazin-1-one

Base Information

Chemical Name:6-tert-Butyl-2-[3-(5-{5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-2-hydroxymethylphenyl]-8-fluoro-2H-phthalazin-1-one
CAS No.:1360056-41-2
Molecular Formula:C₃₉H₄₉FN₆O₆Si
Molecular Weight:744.939
Hs Code.:

6-tert-Butyl-2-[3-(5-{5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-2-hydroxymethylphenyl]-8-fluoro-2H-phthalazin-1-one

Synonyms:6-tert-Butyl-2-[3-(5-{5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-2-hydroxymethylphenyl]-8-fluoro-2H-phthalazin-1-one

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Chemical Property of 6-tert-Butyl-2-[3-(5-{5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-2-hydroxymethylphenyl]-8-fluoro-2H-phthalazin-1-one

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Technology Process of 6-tert-Butyl-2-[3-(5-{5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-2-hydroxymethylphenyl]-8-fluoro-2H-phthalazin-1-one

There total 13 articles about 6-tert-Butyl-2-[3-(5-{5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-2-hydroxymethylphenyl]-8-fluoro-2H-phthalazin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242156-76-8
2-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate

: 1360056-40-1
4-{5-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamino}-6-chloro-2-methyl-2H-pyridazin-3-one

: 1360056-41-2
6-tert-Butyl-2-[3-(5-{5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-2-hydroxymethylphenyl]-8-fluoro-2H-phthalazin-1-one

: 1360057-49-3
C₄₁H₅₁FN₆O₇Si

Guidance literature:: With potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In water; butan-1-ol; at 110 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1379578-05-8
5-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamine

: 1360056-41-2
6-tert-Butyl-2-[3-(5-{5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-2-hydroxymethylphenyl]-8-fluoro-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 48 h / 95 - 105 °C

2.1: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / butan-1-ol; water / 1.5 h / 110 °C / Inert atmosphere

2.2: 20 h / 60 °C

With potassium phosphate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 1,4-dioxane; water; butan-1-ol;

Reference yield:

: 41288-96-4
6-chloropyridine-3-ol

: 1360056-41-2
6-tert-Butyl-2-[3-(5-{5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-2-hydroxymethylphenyl]-8-fluoro-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 30 h / 0 - 25 °C

2.1: boron trifluoride diethyl etherate / 0 - 20 °C

3.1: 1H-imidazole / dmap / N,N-dimethyl-formamide / 25 °C

4.1: lithium hexamethyldisilazane / CyJohnPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 15 h / 90 °C / Inert atmosphere

5.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 48 h / 95 - 105 °C

6.1: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / butan-1-ol; water / 1.5 h / 110 °C / Inert atmosphere

6.2: 20 h / 60 °C

With 1H-imidazole; potassium phosphate; boron trifluoride diethyl etherate; caesium carbonate; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; CyJohnPhos; XPhos; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; butan-1-ol;