6-tert-Butyl-8-fluoro-2-(3-{5-[5-((S)-2-hydroxy-3-methoxy-propoxy)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

Base Information

Chemical Name:6-tert-Butyl-8-fluoro-2-(3-{5-[5-((S)-2-hydroxy-3-methoxy-propoxy)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one
CAS No.:1360055-17-9
Molecular Formula:C₃₃H₃₅FN₆O₆
Molecular Weight:630.676
Hs Code.:

6-tert-Butyl-8-fluoro-2-(3-{5-[5-((S)-2-hydroxy-3-methoxy-propoxy)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

Synonyms:6-tert-Butyl-8-fluoro-2-(3-{5-[5-((S)-2-hydroxy-3-methoxy-propoxy)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

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Chemical Property of 6-tert-Butyl-8-fluoro-2-(3-{5-[5-((S)-2-hydroxy-3-methoxy-propoxy)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

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Technology Process of 6-tert-Butyl-8-fluoro-2-(3-{5-[5-((S)-2-hydroxy-3-methoxy-propoxy)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

There total 8 articles about 6-tert-Butyl-8-fluoro-2-(3-{5-[5-((S)-2-hydroxy-3-methoxy-propoxy)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360056-41-2
6-tert-Butyl-2-[3-(5-{5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-2-hydroxymethylphenyl]-8-fluoro-2H-phthalazin-1-one

: 1360055-17-9
6-tert-Butyl-8-fluoro-2-(3-{5-[5-((S)-2-hydroxy-3-methoxy-propoxy)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

Guidance literature:: 6-tert-Butyl-2-[3-(5-{5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamino}-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-2-hydroxymethylphenyl]-8-fluoro-2H-phthalazin-1-one; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 1h;

With water; In tetrahydrofuran;

Reference yield:

: 1379578-05-8
5-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-propoxy]-pyridin-2-ylamine

: 1360055-17-9
6-tert-Butyl-8-fluoro-2-(3-{5-[5-((S)-2-hydroxy-3-methoxy-propoxy)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 48 h / 95 - 105 °C

2.1: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / butan-1-ol; water / 1.5 h / 110 °C / Inert atmosphere

2.2: 20 h / 60 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 25 °C

With potassium phosphate; tetrabutyl ammonium fluoride; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; water; butan-1-ol;

Reference yield:

: 41288-96-4
6-chloropyridine-3-ol

: 1360055-17-9
6-tert-Butyl-8-fluoro-2-(3-{5-[5-((S)-2-hydroxy-3-methoxy-propoxy)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-2-hydroxymethyl-phenyl)-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 30 h / 0 - 25 °C

2.1: boron trifluoride diethyl etherate / 0 - 20 °C

3.1: 1H-imidazole / dmap / N,N-dimethyl-formamide / 25 °C

4.1: lithium hexamethyldisilazane / CyJohnPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 15 h / 90 °C / Inert atmosphere

5.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 48 h / 95 - 105 °C

6.1: potassium phosphate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / butan-1-ol; water / 1.5 h / 110 °C / Inert atmosphere

6.2: 20 h / 60 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 25 °C

With 1H-imidazole; potassium phosphate; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; caesium carbonate; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; CyJohnPhos; XPhos; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; butan-1-ol;