1-(3,4-difluorobenzyl)-4-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

Base Information

Chemical Name:1-(3,4-difluorobenzyl)-4-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde
CAS No.:1418718-92-9
Molecular Formula:C₁₆H₁₁F₂IN₂O
Molecular Weight:412.177
Hs Code.:

Synonyms:1-(3,4-difluorobenzyl)-4-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

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Chemical Property of 1-(3,4-difluorobenzyl)-4-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

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Technology Process of 1-(3,4-difluorobenzyl)-4-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

There total 8 articles about 1-(3,4-difluorobenzyl)-4-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.2%

: 1418718-89-4
(1-(3,4-difluorobenzyl)-4-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol

: 1418718-92-9
1-(3,4-difluorobenzyl)-4-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 0 - 20 ℃; for 4h; under 760.051 Torr;

Reference yield:

: 34036-07-2
3,4 difluorobenzaldehyde

: 1418718-92-9
1-(3,4-difluorobenzyl)-4-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1.1: benzene / 3 h / 130 °C / 760.05 Torr

1.2: 18 h / 0 - 20 °C / 760.05 Torr

2.1: toluene-4-sulfonic acid / dichloromethane / 18 h / 20 °C / 760.05 Torr

2.2: 2 h / 70 °C / 760.05 Torr

3.1: toluene-4-sulfonic acid / toluene / 1 h / 155 °C / 760.05 Torr / Reflux

3.2: 1 h / 0 - 145 °C / 760.05 Torr

4.1: sodium nitrite; water; sulfuric acid / 1,4-dioxane / 6.17 h / 0 - 20 °C / 760.05 Torr

5.1: pyridine / acetonitrile / 1.17 h / 0 - 20 °C / 760.05 Torr

6.1: sodium iodide; hydrogenchloride / acetonitrile; water / 2 h / 60 °C / 760.05 Torr

7.1: diisobutylaluminium hydride / dichloromethane; toluene / 3.33 h / -55 - 0 °C / 760.05 Torr

8.1: pyridinium chlorochromate / dichloromethane / 4 h / 0 - 20 °C / 760.05 Torr

With pyridine; hydrogenchloride; sulfuric acid; water; diisobutylaluminium hydride; toluene-4-sulfonic acid; pyridinium chlorochromate; sodium iodide; sodium nitrite; In 1,4-dioxane; dichloromethane; water; toluene; acetonitrile; benzene;

Reference yield:

: (3,4-difluoro-benzyl)-(2,2-dimethoxy-ethyl)-amine

: 1418718-92-9
1-(3,4-difluorobenzyl)-4-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 18 h / 20 °C / 760.05 Torr

1.2: 2 h / 70 °C / 760.05 Torr

2.1: toluene-4-sulfonic acid / toluene / 1 h / 155 °C / 760.05 Torr / Reflux

2.2: 1 h / 0 - 145 °C / 760.05 Torr

3.1: sodium nitrite; water; sulfuric acid / 1,4-dioxane / 6.17 h / 0 - 20 °C / 760.05 Torr

4.1: pyridine / acetonitrile / 1.17 h / 0 - 20 °C / 760.05 Torr

5.1: sodium iodide; hydrogenchloride / acetonitrile; water / 2 h / 60 °C / 760.05 Torr

6.1: diisobutylaluminium hydride / dichloromethane; toluene / 3.33 h / -55 - 0 °C / 760.05 Torr

7.1: pyridinium chlorochromate / dichloromethane / 4 h / 0 - 20 °C / 760.05 Torr

With pyridine; hydrogenchloride; sulfuric acid; water; diisobutylaluminium hydride; toluene-4-sulfonic acid; pyridinium chlorochromate; sodium iodide; sodium nitrite; In 1,4-dioxane; dichloromethane; water; toluene; acetonitrile;