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34036-07-2

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34036-07-2 Usage

Chemical Properties

Light Yellow Clear Liquid

Uses

Different sources of media describe the Uses of 34036-07-2 differently. You can refer to the following data:
1. 3,4-Difluorobenzaldehyde is used in the synthesis of fluorine-substituted analogs of Curcumin (C838500), as chemopreventive and/or therapeutic agents against cancers and/or against the development of drug-resistant cancer.
2. 3,4-Difluorobenzaldehyde was used in the synthesis of 3-benzylidene 20,29-dihydrobetulinic acid derivatives.
3. Metabolic

Check Digit Verification of cas no

The CAS Registry Mumber 34036-07-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,0,3 and 6 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 34036-07:
(7*3)+(6*4)+(5*0)+(4*3)+(3*6)+(2*0)+(1*7)=82
82 % 10 = 2
So 34036-07-2 is a valid CAS Registry Number.
InChI:InChI=1/C4H8FNO2/c5-3(1-2-6)4(7)8/h3H,1-2,6H2,(H,7,8)

34036-07-2 Well-known Company Product Price

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  • Alfa Aesar

  • (A14028)  3,4-Difluorobenzaldehyde, 98%   

  • 34036-07-2

  • 5g

  • 434.0CNY

  • Detail
  • Alfa Aesar

  • (A14028)  3,4-Difluorobenzaldehyde, 98%   

  • 34036-07-2

  • 25g

  • 1502.0CNY

  • Detail

34036-07-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,4-Difluorobenzaldehyde

1.2 Other means of identification

Product number -
Other names 3,4-diflourobenzaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:34036-07-2 SDS

34036-07-2Synthetic route

1-bromo-3,4-difluorobenzene
348-61-8

1-bromo-3,4-difluorobenzene

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

Conditions
ConditionsYield
Stage #1: 1-bromo-3,4-difluorobenzene With magnesium; 3,4-difluorophenylmagnesium bromide In tetrahydrofuran; toluene at 0.7 - 30℃; for 1h; Inert atmosphere; Molecular sieve;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; toluene at 10 - 15℃; for 1.5h; Reagent/catalyst; Solvent; Temperature; Molecular sieve; Inert atmosphere;
96.2%
Stage #1: 1-bromo-3,4-difluorobenzene With iodine; magnesium In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
63%
isopropyl chloride
75-29-6

isopropyl chloride

1-bromo-3,4-difluorobenzene
348-61-8

1-bromo-3,4-difluorobenzene

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

Conditions
ConditionsYield
Stage #1: isopropyl chloride With iodine; magnesium In tetrahydrofuran at 20 - 40℃; for 5.66667h; Inert atmosphere;
Stage #2: 1-bromo-3,4-difluorobenzene In tetrahydrofuran at 0 - 10℃;
Stage #3: N,N-dimethyl-formamide In tetrahydrofuran at 0 - 10℃; for 0.666667h;
86%
1-bromo-3,4-difluorobenzene
348-61-8

1-bromo-3,4-difluorobenzene

formic acid ethyl ester
109-94-4

formic acid ethyl ester

A

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

B

bis(3,4-difluorophenyl)methanol
182192-98-9

bis(3,4-difluorophenyl)methanol

Conditions
ConditionsYield
With n-butyllithium In diethyl ether; hexane 1.) -78 deg C, 30 min, 2.) -78 to 20 deg C, overnight;A 5.6%
B 80%
C14H8F4O

C14H8F4O

A

3,4-Difluorobenzonitrile
64248-62-0

3,4-Difluorobenzonitrile

B

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

Conditions
ConditionsYield
With sodium azide; copper(II) choride dihydrate; oxygen In N,N-dimethyl-formamide at 100℃; for 10h; Schlenk technique; Sealed tube;A 69%
B 65%
(3,4-difluorophenyl)methanol
85118-05-4

(3,4-difluorophenyl)methanol

A

3,4-Difluorobenzoic acid
455-86-7

3,4-Difluorobenzoic acid

B

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

Conditions
ConditionsYield
With peracetic acid; C24H29INO5 In acetic acid at 30℃; for 48h;A 62%
B 18%
3,4-difluorotoluene
2927-34-6

3,4-difluorotoluene

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

Conditions
ConditionsYield
With sodium molybdate; dihydrogen peroxide; cobalt(II) acetate; acetic acid; sodium bromide at 65℃; Temperature;30.7%
With bromine; calcium carbonate In dichloromethane
With bromine; calcium carbonate In dichloromethane; water
Dichloromethyl methyl ether
4885-02-3

Dichloromethyl methyl ether

ortho-difluorobenzene
367-11-3

ortho-difluorobenzene

A

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

B

tris(3,4-difluorophenyl)methane
32248-39-8

tris(3,4-difluorophenyl)methane

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethaneA 12%
B 26 %Chromat.
1-bromo-3,4-difluorobenzene
348-61-8

1-bromo-3,4-difluorobenzene

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

Conditions
ConditionsYield
With sodium formate; bis(triphenylphosphine)palladium(II) dichloride In CO; N,N-dimethyl-formamide
ortho-difluorobenzene
367-11-3

ortho-difluorobenzene

A

5,6-difluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-indenyl-3-acetic acid

5,6-difluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-indenyl-3-acetic acid

B

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

Conditions
ConditionsYield
aluminium trichloride In dichloromethyl methylether; dichloromethane
water
7732-18-5

water

3,4-difluorotoluene
2927-34-6

3,4-difluorotoluene

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

Conditions
ConditionsYield
With bromine; calcium carbonate In dichloromethane
With bromine; calcium carbonate In dichloromethane
With bromine; calcium carbonate In dichloromethane
With bromine; calcium carbonate In dichloromethane
dichloromethyl methylether

dichloromethyl methylether

ortho-difluorobenzene
367-11-3

ortho-difluorobenzene

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

Conditions
ConditionsYield
aluminium trichloride In dichloromethane
aluminium trichloride In dichloromethane
dichloromethyl methylether

dichloromethyl methylether

ortho-difluorobenzene
367-11-3

ortho-difluorobenzene

A

5,6-Difluoro-2-Methyl-1-(ρ-Methylsulfinylbenzylidene)-Indenyl-3-Acetic Acid

5,6-Difluoro-2-Methyl-1-(ρ-Methylsulfinylbenzylidene)-Indenyl-3-Acetic Acid

B

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

Conditions
ConditionsYield
aluminium trichloride In dichloromethane
N-[(3,4-difluorophenyl)methylene]-2,2-dimethoxyethanamine

N-[(3,4-difluorophenyl)methylene]-2,2-dimethoxyethanamine

A

2-(3,4-difluorobenzyl)pyrazine
1009309-81-2

2-(3,4-difluorobenzyl)pyrazine

B

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

Conditions
ConditionsYield
With trifluoroacetic acid at 75℃; for 0.666667h;
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

diethylzinc
557-20-0

diethylzinc

(S)-1-(3,4-Difluoro-phenyl)-propan-1-ol
847448-30-0

(S)-1-(3,4-Difluoro-phenyl)-propan-1-ol

Conditions
ConditionsYield
With titanium(IV) isopropylate; N,N’-(1R,2R)-cyclohexane-1,2-diylbis(1,1,1-trifluoromethanesulfonamide) In toluene at -78℃;100%
Stage #1: diethylzinc With titanium(IV) isopropylate; C48H34O4 In diethyl ether; hexane at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 3,4 difluorobenzaldehyde In diethyl ether; hexane at 20℃; for 5h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
92%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

N-methoxylamine hydrochloride
593-56-6

N-methoxylamine hydrochloride

3,4-difluorobenzaldehyde O-methyloxime
646051-28-7

3,4-difluorobenzaldehyde O-methyloxime

Conditions
ConditionsYield
100%
2-(3-fluoro-4-methoxyphenyl)-2-[(trimethylsilyl)oxy]acetonitrile
177755-45-2

2-(3-fluoro-4-methoxyphenyl)-2-[(trimethylsilyl)oxy]acetonitrile

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

3,4-difluoro-α-[(trimethylsilyl)oxy]benzeneacetonitrile
177755-69-0

3,4-difluoro-α-[(trimethylsilyl)oxy]benzeneacetonitrile

Conditions
ConditionsYield
100%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

2-(3,4-dimethoxyphenyl)-ethylamine
120-20-7

2-(3,4-dimethoxyphenyl)-ethylamine

N-(3',4'-difluorophenyl)methyl-3,4-dimethoxyphenethylamine
355815-40-6

N-(3',4'-difluorophenyl)methyl-3,4-dimethoxyphenethylamine

Conditions
ConditionsYield
Stage #1: 3,4 difluorobenzaldehyde; 2-(3,4-dimethoxyphenyl)-ethylamine In methanol for 2 - 3h; Reflux;
Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 1h; Cooling;
100%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

5-(aminomethyl)-2-chloropyridine
97004-04-1

5-(aminomethyl)-2-chloropyridine

C13H11ClF2N2

C13H11ClF2N2

Conditions
ConditionsYield
Stage #1: 3,4 difluorobenzaldehyde; 5-(aminomethyl)-2-chloropyridine In methanol at 20℃;
Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 0.416667h;
99.1%
4-methoxy-5H-furan-2-one
69556-70-3

4-methoxy-5H-furan-2-one

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

C12H10F2O4

C12H10F2O4

Conditions
ConditionsYield
Stage #1: 4-methoxy-5H-furan-2-one With n-butyllithium
Stage #2: 3,4 difluorobenzaldehyde In tetrahydrofuran at -78 - 20℃;
99%
Stage #1: 4-methoxy-5H-furan-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h; Inert atmosphere;
Stage #2: 3,4 difluorobenzaldehyde In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere;
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

dimethyl amine
124-40-3

dimethyl amine

C9H10FNO

C9H10FNO

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In dimethyl sulfoxide; benzene at 90℃; for 6h;99%
With tetrabutylammomium bromide; potassium carbonate In dimethyl sulfoxide at 90℃; for 7h; Inert atmosphere;92%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

ethyl (triphenylphosphoranylidene)acetate
1099-45-2

ethyl (triphenylphosphoranylidene)acetate

ethyl (2E)-3-(3,4-difluorophenyl)prop-2-enoate

ethyl (2E)-3-(3,4-difluorophenyl)prop-2-enoate

Conditions
ConditionsYield
In dichloromethane at 20℃; for 16h;99%
In toluene at 80℃; for 1h;67%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

2-(trans-4-butylcyclohexyl)-1,3-propanediol
132310-87-3

2-(trans-4-butylcyclohexyl)-1,3-propanediol

trans-5-(trans-4-butylcyclohexyl)-2-(3,4-difluorophenyl)-1,3-dioxane

trans-5-(trans-4-butylcyclohexyl)-2-(3,4-difluorophenyl)-1,3-dioxane

Conditions
ConditionsYield
With hydrogenchloride; calcium chloride In water at 50℃; for 9h; Inert atmosphere; stereoselective reaction;99%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
25015-63-8

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

2-((3,4-difluorobenzyl)oxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-((3,4-difluorobenzyl)oxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
With C34H28N6Zn In neat (no solvent) at 20℃; for 2h; Glovebox; Schlenk technique;99%
piperidine
110-89-4

piperidine

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

methyl 2-{(3,4-difluorophenyl)methylene}-3-oxobutyrate

methyl 2-{(3,4-difluorophenyl)methylene}-3-oxobutyrate

Conditions
ConditionsYield
With acetic acid In ethyl acetate; benzene98.3%
With acetic acid In ethyl acetate; benzene98.3%
With acetic acid In ethyl acetate; benzene98.3%
With acetic acid In ethyl acetate; benzene98.3%
With acetic acid In ethyl acetate; benzene98.3%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

bis(3,4-difluorophenyl)methanol
182192-98-9

bis(3,4-difluorophenyl)methanol

Conditions
ConditionsYield
Stage #1: 1-bromo-3,4-difluorobenzene With n-butyllithium In diethyl ether; hexane at -78℃; for 3h;
Stage #2: 3,4 difluorobenzaldehyde at -70 - 20℃;
98%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

4,4-ethylenedioxy-piperidine
177-11-7

4,4-ethylenedioxy-piperidine

8-(3,4-difluorobenzyl)-1,4-dioxa-8-azaspiro[4.5]decane
935777-21-2

8-(3,4-difluorobenzyl)-1,4-dioxa-8-azaspiro[4.5]decane

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 18h;98%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

2-(4-(((1-((1-(2-hydrazinyl-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d]imidazol-2-yl)thio)methyl)-1H-1,2,3-triazol-1-yl)acetohydrazide

2-(4-(((1-((1-(2-hydrazinyl-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d]imidazol-2-yl)thio)methyl)-1H-1,2,3-triazol-1-yl)acetohydrazide

N'-(3,4-difluorobenzylidene)-2-(4-(((1-((1-(2-(2-(3,4-difluorobenzylidene)-hydrazinyl)-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d]imidazol-2-yl)-thio)methyl)-1H-1,2,3-triazol-1-yl)acetohydrazide

N'-(3,4-difluorobenzylidene)-2-(4-(((1-((1-(2-(2-(3,4-difluorobenzylidene)-hydrazinyl)-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl)-1H-benzo[d]imidazol-2-yl)-thio)methyl)-1H-1,2,3-triazol-1-yl)acetohydrazide

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water for 0.0666667h; Sealed tube; Microwave irradiation; Green chemistry;98%
carbon tetrabromide
558-13-4

carbon tetrabromide

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

3,4-Difluoro-β,β'-dibromostyrene
159957-01-4

3,4-Difluoro-β,β'-dibromostyrene

Conditions
ConditionsYield
Stage #1: carbon tetrabromide With triphenylphosphine In dichloromethane at 0℃; for 1h; Inert atmosphere;
Stage #2: 3,4 difluorobenzaldehyde In dichloromethane at 20℃; for 2h; Inert atmosphere;
97%
With triphenylphosphine; zinc 1.) CH2Cl2, 48 h, 2.) 3 h; Multistep reaction;
With triphenylphosphine; zinc 1.) CH2Cl2, r.t., 48 h, 2.) 2 h; Multistep reaction;
1-(7-hydroxy-2,2-dimethylchroman-6-yl)ethanone
31273-58-2

1-(7-hydroxy-2,2-dimethylchroman-6-yl)ethanone

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

3-(3,4-difluoro-phenyl)-1-(7-hydroxy-2,2-dimethyl-chroman-6-yl)-propenone
1416511-87-9

3-(3,4-difluoro-phenyl)-1-(7-hydroxy-2,2-dimethyl-chroman-6-yl)-propenone

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 20℃; for 48h; Claisen-Schmidt Condensation;97%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

diethyl 4-methylbenzylphosphonate
3762-25-2

diethyl 4-methylbenzylphosphonate

(E)-1,2-difluoro-4-(4-methylstyryl)benzene

(E)-1,2-difluoro-4-(4-methylstyryl)benzene

Conditions
ConditionsYield
Stage #1: diethyl 4-methylbenzylphosphonate With sodium hydride In tetrahydrofuran at 0 - 5℃; for 0.5h; Horner-Wadsworth-Emmons Olefination;
Stage #2: 3,4 difluorobenzaldehyde In tetrahydrofuran at 0 - 20℃; for 20h; Horner-Wadsworth-Emmons Olefination;
97%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

glycine ethyl ester hydrochloride
5680-79-5

glycine ethyl ester hydrochloride

(E)-methyl 2-((3,4-difluorobenz)amino)acetate

(E)-methyl 2-((3,4-difluorobenz)amino)acetate

Conditions
ConditionsYield
Stage #1: glycine ethyl ester hydrochloride With magnesium sulfate; triethylamine In dichloromethane at 20℃; for 1h; Inert atmosphere;
Stage #2: 3,4 difluorobenzaldehyde In dichloromethane at 20℃; for 12h;
97%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

4-methoxy-aniline
104-94-9

4-methoxy-aniline

[1-(3,4-Difluoro-phenyl)-meth-(E)-ylidene]-(4-methoxy-phenyl)-amine
224433-74-3

[1-(3,4-Difluoro-phenyl)-meth-(E)-ylidene]-(4-methoxy-phenyl)-amine

Conditions
ConditionsYield
With DOWEX 50W X8-400 In benzene Heating;96%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

5-(trifluoromethyl)pyridin-3-ol
186593-14-6

5-(trifluoromethyl)pyridin-3-ol

3-fluoro-4-((5-(trifluoromethyl)pyridin-3-yl)oxy)benzaldehyde
1620579-56-7

3-fluoro-4-((5-(trifluoromethyl)pyridin-3-yl)oxy)benzaldehyde

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 16h;96%
4-amino-5-methyl-2,4-dihydro-[1,2,4]triazole-3-thione
20939-15-5

4-amino-5-methyl-2,4-dihydro-[1,2,4]triazole-3-thione

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

(E)-4-((3,4-difluorobenzylidene)amino)-2,4-dihydro-5-methyl-3H-1,2,4-triazole-3-thione

(E)-4-((3,4-difluorobenzylidene)amino)-2,4-dihydro-5-methyl-3H-1,2,4-triazole-3-thione

Conditions
ConditionsYield
With acetic acid In ethanol for 0.0833333h; Time; Microwave irradiation;96%
malonic acid
141-82-2

malonic acid

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

(E)-3-(3,4-difluorophenyl)acrylic acid
112897-97-9

(E)-3-(3,4-difluorophenyl)acrylic acid

Conditions
ConditionsYield
With piperidine; pyridine at 90℃; for 2h; Inert atmosphere;95%
With piperidine; pyridine for 4h; Reagent/catalyst; Temperature; Knoevenagel Condensation; Reflux; diastereoselective reaction;92%
With piperidine In pyridine at 65℃; for 4h;87%
2-(3-hydroxy-4-methoxyphenyl)-1,3-dioxolane
181758-85-0

2-(3-hydroxy-4-methoxyphenyl)-1,3-dioxolane

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

C17H15FO5

C17H15FO5

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 17h;95%
1-(4-(4-benzylpiperidin-1-yl)phenyl)ethanone
1175944-69-0

1-(4-(4-benzylpiperidin-1-yl)phenyl)ethanone

3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

(E)-1-(4-(4-benzylpiperidin-1-yl)phenyl)-3-(3,4-difluorophenyl)prop-2-en-1-one

(E)-1-(4-(4-benzylpiperidin-1-yl)phenyl)-3-(3,4-difluorophenyl)prop-2-en-1-one

Conditions
ConditionsYield
With sodium hydroxide In methanol at 60℃; for 0.5h; Claisen-Schmidt Condensation; Microwave irradiation;95%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

thiosemicarbazide
79-19-6

thiosemicarbazide

(E)-2-(3,4-difluoro-benzylidene)-hydrazine-carbothioamide
1570052-89-9

(E)-2-(3,4-difluoro-benzylidene)-hydrazine-carbothioamide

Conditions
ConditionsYield
With acetic acid In ethanol; water for 24h; Inert atmosphere; Schlenk technique; Reflux;95%
With acetic acid In ethanol Reflux;
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

1,3,5-tris(3,4-dimethoxybenzyl)benzene
1393084-21-3

1,3,5-tris(3,4-dimethoxybenzyl)benzene

C54H30F6O6
1569689-06-0

C54H30F6O6

Conditions
ConditionsYield
With iron(III) chloride; acetic anhydride In nitromethane; dichloromethane at 20℃; Inert atmosphere;95%
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

2-(7-fluoro-2-methoxyquinolin-8-yl)acetohydrazide

2-(7-fluoro-2-methoxyquinolin-8-yl)acetohydrazide

(E)-N'-(3,4-difluorobenzylidene)-2-(7-fluoro-2-methoxyquinolin-8-yl)acetohydrazide

(E)-N'-(3,4-difluorobenzylidene)-2-(7-fluoro-2-methoxyquinolin-8-yl)acetohydrazide

Conditions
ConditionsYield
In ethanol for 4h; Reflux;95%
In ethanol for 4h; Reflux;
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

thiosemicarbazide
79-19-6

thiosemicarbazide

3,4-difluoro-benzaldehyde thiosemicarbazone

3,4-difluoro-benzaldehyde thiosemicarbazone

Conditions
ConditionsYield
With sulfuric acid In ethanol at 40℃; for 4h;95%
With acetic acid In ethanol at 65 - 70℃; for 10h;
3,4 difluorobenzaldehyde
34036-07-2

3,4 difluorobenzaldehyde

3-fluoro-1-diethylphosphonomethyl-benzene
63909-57-9

3-fluoro-1-diethylphosphonomethyl-benzene

(E)-1,2-difluoro-4-(3-fluorostyryl)benzene

(E)-1,2-difluoro-4-(3-fluorostyryl)benzene

Conditions
ConditionsYield
Stage #1: 3-fluoro-1-diethylphosphonomethyl-benzene With sodium hydride In tetrahydrofuran at 0 - 5℃; for 0.5h; Horner-Wadsworth-Emmons Olefination;
Stage #2: 3,4 difluorobenzaldehyde In tetrahydrofuran at 0 - 20℃; for 20h; Horner-Wadsworth-Emmons Olefination;
95%

34036-07-2Relevant articles and documents

Direct formylation of fluorine-containing aromatics with dichloromethyl alkyl ethers

Warashina, Takuya,Matsuura, Daisuke,Kimura, Yoshikazu

, p. 587 - 593 (2019/07/22)

Formylations of fluorine-containing aromatic compounds with dichloromethyl alkyl ethers have been investigated. Dichloromethyl propyl ether and dichloromethyl butyl ether have been applied for the formylation of fluorine-containing anisoles to give the corresponding aldehydes in good yields. Application of these ethers is preferable to that of methyl ether, which is prepared from volatile methyl formate. Reaction of fluorine-containing phenols with these dichloromethyl alkyl ethers did not give salicylaldehyde derivatives, leading instead to corresponding aryl formates in high yields. A plausible mechanism is discussed.

A 3, 4 - difluoro toluene of continuous oxidation to prepare 3, 4 - difluorobenzaldehyde method (by machine translation)

-

Paragraph 0004; 0032-0034, (2017/07/07)

The invention relates to a 3, 4 - difluoro toluene of continuous oxidation to prepare 3, 4 - difluorobenzaldehyde method, which belongs to the technical field of organic synthesis process. The method is characterized in that the 3, 4 - difluoro toluene compound as a raw material, cobalt, molybdenum, one or several of the bromine metal ion complex as catalyst, hydrogen peroxide as the oxidizing agent, acetic acid as solvent, in the tubular reactor continuous will be 3, 4 - difluoro benzene oxidation process for preparing 3, 4 - difluorobenzaldehyde process technology. Mild condition of this method, the reaction time is short, high utilization rate of raw materials, can be realized in the effective control of the reaction process, safe and stable, continuous operation, the production efficiency is high. (by machine translation)

Copper-catalyzed aerobic oxidative cleavage of C-C bonds in epoxides leading to aryl nitriles and aryl aldehydes

Gu, Lijun,Jin, Cheng

supporting information, p. 6572 - 6575 (2015/04/14)

Novel copper-catalyzed aerobic synthesis of aryl nitriles and aldehydes from epoxides via C-C single bond cleavage has been discovered. This reaction provides a practical method toward the synthesis of aryl nitriles and aldehydes, which are versatile intermediates and building blocks in organic synthesis. This journal is

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