tert-butyl N-[(1S,2R)-2-hydroxy-2-(3-methoxyphenyl)-1-methyl-ethyl] carbamate

Base Information

Chemical Name:tert-butyl N-[(1S,2R)-2-hydroxy-2-(3-methoxyphenyl)-1-methyl-ethyl] carbamate
CAS No.:1034153-26-8
Molecular Formula:C₁₅H₂₃NO₄
Molecular Weight:281.352
Hs Code.:

Synonyms:tert-butyl N-[(1S,2R)-2-hydroxy-2-(3-methoxyphenyl)-1-methyl-ethyl] carbamate

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Chemical Property of tert-butyl N-[(1S,2R)-2-hydroxy-2-(3-methoxyphenyl)-1-methyl-ethyl] carbamate

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Technology Process of tert-butyl N-[(1S,2R)-2-hydroxy-2-(3-methoxyphenyl)-1-methyl-ethyl] carbamate

There total 3 articles about tert-butyl N-[(1S,2R)-2-hydroxy-2-(3-methoxyphenyl)-1-methyl-ethyl] carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1034153-28-0
tert-butyl N-[(1S)-2-(3-methoxyphenyl)-1-methyl-2-oxo-ethyl]carbamate

: 1034153-26-8
tert-butyl N-[(1S,2R)-2-hydroxy-2-(3-methoxyphenyl)-1-methyl-ethyl] carbamate

Guidance literature:: With aluminum isopropoxide; isopropyl alcohol; In toluene; at 50 ℃; for 16h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b01215

Reference yield:

: 15761-38-3
L-N-Boc-Ala

: 1034153-26-8
tert-butyl N-[(1S,2R)-2-hydroxy-2-(3-methoxyphenyl)-1-methyl-ethyl] carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 16 h / 0 - 15 °C / Industrial scale

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1.66 h / 10 - 15 °C / Industrial scale

2.2: 10 - 15 °C / Industrial scale

3.1: aluminum isopropoxide / toluene; isopropyl alcohol / 13 h / 50 °C / Industrial scale

With isopropylmagnesium chloride; aluminum isopropoxide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; isopropyl alcohol; toluene;

Reference yield:

: 36282-40-3
(3-methoxyphenyl)magnesium bromide

: 146553-06-2,87694-49-3
tert-butyl {(S)-1-[methoxy(methyl)amino]-1-oxopropan-2-yl}carbamate

: 1034153-26-8
tert-butyl N-[(1S,2R)-2-hydroxy-2-(3-methoxyphenyl)-1-methyl-ethyl] carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.66 h / 10 - 15 °C / Industrial scale

1.2: 10 - 15 °C / Industrial scale

2.1: aluminum isopropoxide / toluene; isopropyl alcohol / 13 h / 50 °C / Industrial scale

With isopropylmagnesium chloride; aluminum isopropoxide; In tetrahydrofuran; isopropyl alcohol; toluene;