5-(3,5-difluorobenzoyl)-4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[5,4-c]pyridine

Base Information

Chemical Name:5-(3,5-difluorobenzoyl)-4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[5,4-c]pyridine
CAS No.:1363281-33-7
Molecular Formula:C₂₀H₁₆F₂N₂O₃
Molecular Weight:370.355
Hs Code.:

Synonyms:5-(3,5-difluorobenzoyl)-4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[5,4-c]pyridine

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Chemical Property of 5-(3,5-difluorobenzoyl)-4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[5,4-c]pyridine

Chemical Property:

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Technology Process of 5-(3,5-difluorobenzoyl)-4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[5,4-c]pyridine

There total 11 articles about 5-(3,5-difluorobenzoyl)-4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[5,4-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 455-40-3
3,5-difluorobenzoic acid

: 1363286-28-5
2-(phenoxymethyl)-4,5,6,7-tetrahydrooxazolo[5,4-c]pyridine

: 1363281-33-7
5-(3,5-difluorobenzoyl)-4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[5,4-c]pyridine

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 95629-02-0
ethyl 3-bromo-4-oxo-1-piperidinecarboxylate

: 1363281-33-7
5-(3,5-difluorobenzoyl)-4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[5,4-c]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1: 60 h / 125 °C / silica gel

2: 4-methylmorpholine N-oxide / osmium(VIII) oxide / water; tert-butyl alcohol; tetrahydrofuran; methanol / 16 h / 20 °C

3: sodium periodate / water; tetrahydrofuran; methanol / 2 h / 20 °C

4: sodium tetrahydroborate; methanol / 0.33 h / 0 - 20 °C

5: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0.33 h / 0 - 20 °C

6: water; lithium hydroxide / 1,4-dioxane / 90 h / 125 °C / Inert atmosphere

7: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; sodium periodate; di-tert-butyl-diazodicarboxylate; water; benzotriazol-1-ol; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hydroxide; osmium(VIII) oxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 1363281-33-7
5-(3,5-difluorobenzoyl)-4,5,6,7-tetrahydro-2-(phenoxymethyl)-oxazolo[5,4-c]pyridine

Guidance literature:: Multi-step reaction with 8 steps

1: bromine; hydrogen bromide / water; tetrahydrofuran / 0.25 h / 0 - 20 °C

2: 60 h / 125 °C / silica gel

3: 4-methylmorpholine N-oxide / osmium(VIII) oxide / water; tert-butyl alcohol; tetrahydrofuran; methanol / 16 h / 20 °C

4: sodium periodate / water; tetrahydrofuran; methanol / 2 h / 20 °C

5: sodium tetrahydroborate; methanol / 0.33 h / 0 - 20 °C

6: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0.33 h / 0 - 20 °C

7: water; lithium hydroxide / 1,4-dioxane / 90 h / 125 °C / Inert atmosphere

8: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; sodium periodate; di-tert-butyl-diazodicarboxylate; water; hydrogen bromide; bromine; benzotriazol-1-ol; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hydroxide; osmium(VIII) oxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;