4-hydroxy-3-(((1R,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl)benzoic acid

Base Information

Chemical Name:4-hydroxy-3-(((1R,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl)benzoic acid
CAS No.:752211-90-8
Molecular Formula:C₂₂H₃₂O₄
Molecular Weight:360.494
Hs Code.:

Synonyms:4-hydroxy-3-(((1R,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl)benzoic acid

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Chemical Property of 4-hydroxy-3-(((1R,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl)benzoic acid

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Technology Process of 4-hydroxy-3-(((1R,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl)benzoic acid

There total 9 articles about 4-hydroxy-3-(((1R,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4-(benzyloxy)-3-(((1R,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl)benzoic acid

: 752211-90-8
4-hydroxy-3-(((1R,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl)benzoic acid

Guidance literature:: With 5%-palladium/activated carbon; ammonium formate; In methanol; for 10h; Reflux;
DOI:10.1016/j.ejmech.2021.113912

Reference yield: 77.0%

: 1376654-81-7
C₃₆H₄₄O₄

: 752211-90-8
4-hydroxy-3-(((1R,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl)benzoic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 12h; under 10343.2 Torr;
DOI:10.1021/ja303937y

Reference yield:

: 2973-78-6
3-bromo-4-hydroxybenzylaldehyde

: 752211-90-8
4-hydroxy-3-(((1R,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 90 °C

2: ruphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / water; tert-butyl alcohol / 18 h / 100 °C / Schlenk technique; Inert atmosphere

3: 2-methyl-but-2-ene; sodium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 5 h / 20 °C

4: ammonium formate; 5%-palladium/activated carbon / methanol / 10 h / Reflux

With sodium chlorite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium dihydrogenphosphate; 2-methyl-but-2-ene; 5%-palladium/activated carbon; ammonium formate; potassium carbonate; sodium t-butanolate; ruphos; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2021.113912