allyl 2-benzyl-1-oxo-2,3-dihydro-1H-indene-2-carboxylate

Base Information

• Chemical Name: allyl 2-benzyl-1-oxo-2,3-dihydro-1H-indene-2-carboxylate
• CAS No.: 1362387-27-6
• Molecular Formula: C₂₀H₁₈O₃
• Molecular Weight: 306.361
• Mol file: 1362387-27-6.mol

Synonyms:allyl 2-benzyl-1-oxo-2,3-dihydro-1H-indene-2-carboxylate

Chemical Property of allyl 2-benzyl-1-oxo-2,3-dihydro-1H-indene-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of allyl 2-benzyl-1-oxo-2,3-dihydro-1H-indene-2-carboxylate

There total 2 articles about allyl 2-benzyl-1-oxo-2,3-dihydro-1H-indene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

allyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate + benzyl bromide (100-39-0) → allyl 2-benzyl-1-oxo-2,3-dihydro-1H-indene-2-carboxylate (1362387-27-6)

Guidance literature:

With potassium carbonate; In acetone; at 50 ℃; for 14h; Inert atmosphere;

DOI:10.1021/acs.joc.7b00303

Reference yield:

inden-1-one (83-33-0) → allyl 2-benzyl-1-oxo-2,3-dihydro-1H-indene-2-carboxylate (1362387-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

1.2: 16 h / 20 °C

2.1: potassium carbonate / acetone / 14 h / 50 °C

With sodium hydride; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.1002/chem.201003383

Reference yield: 77.0%

allyl 2-benzyl-1-oxo-2,3-dihydro-1H-indene-2-carboxylate (1362387-27-6) → 2-benzyl-1-indanone (16307-30-5)

Guidance literature:

With formic acid; palladium diacetate; 1,2-bis-(diphenylphosphino)ethane; In 1,4-dioxane; at 40 ℃; for 10h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.7b00303

upstream raw materials:

benzyl bromide

inden-1-one

Downstream raw materials:

2-allyl-2-benzyl-2,3-dihydro-1H-inden-1-one

2-benzyl-1-indanone

(R)-(-)-2-benzylindan-1-one

(S)-(+)-2-benzylindan-1-one