8-[(E)-2-(3-Chloro-phenyl)-vinyl]-3-methyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione

Base Information

Chemical Name:8-[(E)-2-(3-Chloro-phenyl)-vinyl]-3-methyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione
CAS No.:174519-08-5
Molecular Formula:C₁₇H₁₃ClN₄O₂
Molecular Weight:340.769
Hs Code.:

Synonyms:8-[(E)-2-(3-Chloro-phenyl)-vinyl]-3-methyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione

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Chemical Property of 8-[(E)-2-(3-Chloro-phenyl)-vinyl]-3-methyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione

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Technology Process of 8-[(E)-2-(3-Chloro-phenyl)-vinyl]-3-methyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione

There total 6 articles about 8-[(E)-2-(3-Chloro-phenyl)-vinyl]-3-methyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 174519-02-9
(E)-N-(6-Amino-1-methyl-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-chloro-phenyl)-acrylamide

: 174519-08-5
8-[(E)-2-(3-Chloro-phenyl)-vinyl]-3-methyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione

Guidance literature:: With sodium hydroxide; In methanol; Heating;
DOI:10.1055/s-1995-4082

Reference yield:

: 138895-22-4
6-amino-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione

: 174519-08-5
8-[(E)-2-(3-Chloro-phenyl)-vinyl]-3-methyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione

Guidance literature:: Multi-step reaction with 5 steps

1: HNO₂/H⁽¹⁺⁾

2: Na₂S₂O₄, NH₃ / H₂O

3: 71 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / methanol; H₂O / Ambient temperature

4: 96 percent / K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

5: 73 percent / 20 percent aq. NaOH / methanol / Heating

With sodium hydroxide; sodium dithionite; ammonia; hydrogen cation; cis-nitrous acid; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1055/s-1995-4082

Reference yield:

: 146830-75-3
5,6-diamino-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione

: 174519-08-5
8-[(E)-2-(3-Chloro-phenyl)-vinyl]-3-methyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / methanol; H₂O / Ambient temperature

2: 96 percent / K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

3: 73 percent / 20 percent aq. NaOH / methanol / Heating

With sodium hydroxide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1055/s-1995-4082