(R)-1-(5-bromothiophen-2-ylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

Base Information

Chemical Name:(R)-1-(5-bromothiophen-2-ylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine
CAS No.:946398-15-8
Molecular Formula:C₁₆H₁₅BrF₄N₂O₂S₂
Molecular Weight:487.337
Hs Code.:

Synonyms:(R)-1-(5-bromothiophen-2-ylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

Suppliers and Price of (R)-1-(5-bromothiophen-2-ylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-(5-bromothiophen-2-ylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

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Technology Process of (R)-1-(5-bromothiophen-2-ylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

There total 1 articles about (R)-1-(5-bromothiophen-2-ylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 55854-46-1
5-bromo-2-thiophenesulfonyl chloride

(3R)-1-(4-fluoro-2-(trifluoromethyl)phenyl)-3-methylpiperazine: 946399-84-4,1414960-67-0
(3R)-1-(4-fluoro-2-(trifluoromethyl)phenyl)-3-methylpiperazine

: 946398-15-8
(R)-1-(5-bromothiophen-2-ylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 6h;

Reference yield: 68.0%

: 13089-11-7
methyl 3,3,3-trifluoropyruvate

: 946398-15-8
(R)-1-(5-bromothiophen-2-ylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

: 1257229-77-8
methyl 3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanoate

Guidance literature:: (R)-1-(5-bromothiophen-2-ylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

methyl 3,3,3-trifluoropyruvate; In tetrahydrofuran; hexane; at -78 ℃; for 2h;
DOI:10.1021/ml300352x

Reference yield:

: 421-50-1
1,1,1-trifluoro-2-propanone

: 946398-15-8
(R)-1-(5-bromothiophen-2-ylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine

: 946398-52-3
(2S)-1,1,1-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)propan-2-ol

: 946398-53-4
(2R)-1,1,1-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)propan-2-ol

Guidance literature:: (R)-1-(5-bromothiophen-2-ylsulfonyl)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

1,1,1-trifluoro-2-propanone; In tetrahydrofuran; hexane; at -78 - 20 ℃; Overall yield = 91 %; Overall yield = 3.89 mg;
DOI:10.1021/ml300352x