Welcome to LookChem.com Sign In|Join Free


  • or


Post Buying Request

421-50-1 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

421-50-1 Usage

Chemical Properties

1,1,1-Trifluoroacetone is CLEAR COLOURLESS LIQUID


Different sources of media describe the Uses of 421-50-1 differently. You can refer to the following data:
1. 1,1,1-Trifluoroacetone is used as intermediate of bioactive substance and antihypertensive drug, and as effective synthetic building block and trifluoromethyl reaction reagent.
2. 1,1,1-Trifluoroacetone is a general chemical reagent used in the synthesis of glucokinase-glucokinase regulatory protein) GK-GKRP disruptors which may act as potential targets for type II diabetics. Reactant for enantioselective cycloadditions.
3. Used in a synthesis of 2-trifluoromethyl-7-azaindoles starting with 2,6-dihalopyridines. The derived chiral imine was used to prepare enantiopure α-trifluoromethyl alanines and diamines via a Strecker reaction followed by either nitrile hydrolysis or reduction.

Check Digit Verification of cas no

The CAS Registry Mumber 421-50-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,2 and 1 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 421-50:
41 % 10 = 1
So 421-50-1 is a valid CAS Registry Number.

421-50-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (T2921)  1,1,1-Trifluoroacetone (in cylinder without valve) [To use this product charged in cylinder, a valve is required which is sold separately (Product Code:V0030)]  >98.0%(GC)

  • 421-50-1

  • 100g

  • 3,500.00CNY

  • Detail
  • Alfa Aesar

  • (A13556)  1,1,1-Trifluoroacetone, 95%   

  • 421-50-1

  • 25g

  • 1183.0CNY

  • Detail
  • Alfa Aesar

  • (A13556)  1,1,1-Trifluoroacetone, 95%   

  • 421-50-1

  • 100g

  • 2991.0CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017


1.1 GHS Product identifier

Product name 1,1,1-Trifluoroacetone

1.2 Other means of identification

Product number -
Other names 2-Propanone, 1,1,1-trifluoro-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:421-50-1 SDS

421-50-1Relevant articles and documents


Johnson, D.A.,Waugh, A.B.,Hambley, T.W.,Taylor, J.C.

, p. 371 - 378 (1985)

The vapour phase reaction of ammonia and hexafluoroacetylacetone leads to the formation of the new β-keto-amine C5H3F6NO.Crystals of the compound are monoclinic, space group P21/n, a = 10.01(2), b = 19.33(3), c = 8.40(1) Angstroem, β = 82.27(6) deg; final R = 0.044.

Homogeneous liquid-liquid extraction of neodymium(iii) by choline hexafluoroacetylacetonate in the ionic liquid choline bis(trifluoromethylsulfonyl)imide

Onghena, Bieke,Jacobs, Jeroen,Van Meervelt, Luc,Binnemans, Koen

, p. 11566 - 11578 (2014)

The ionic liquid choline bis(trifluoromethylsulfonyl)imide, [Chol][Tf 2N], was used for the extraction of neodymium(iii), in combination with choline hexafluoroacetylacetonate, [Chol][hfac], as the extractant. The binary mixture of [Chol][Tf2N] and water shows temperature-dependent phase behavior, with an upper critical solution temperature of 72 °C. A novel extraction technique, homogeneous liquid-liquid extraction (HLLE), was applied to this solvent system. HLLE is based on the use of thermomorphic solvent mixtures and has the advantage of forming a homogeneous phase during mixing. Extraction is not kinetically hindered by an interface and the extraction equilibrium is reached faster than in the case of heterogeneous mixing in conventional solvent extraction. Several extraction parameters were studied for the extraction of neodymium(iii) with [Chol][hfac]: temperature, pH, extractant concentration and loading of the ionic liquid phase. A speciation study was performed to determine the stoichiometry of the extracted neodymium(iii) complex and a plausible extraction mechanism is proposed. Neodymium is extracted as a tetrakis hexafluoroacetylacetonate complex with one choline cation as counter ion. The crystal structure of the extracted complex showed the presence of a coordination bond between the choline counter ion and the neodymium(iii) center, resulting in a coordination number of nine. The stripping of the loaded neodymium and the influence of acid and extractant concentrations on the phase behavior of the [Chol][Tf2N]-H 2O system were investigated. This journal is the Partner Organisations 2014.

One-electron reduction of methyl(trifluoromethyl)dioxirane by iodide ion. Evidence for an electron-transfer chain reaction mediated by the superoxide ion

Adam, Waldemar,Asensio, Gregorio,Curci, Ruggero,González-Nú?ez, Maria Elena,Mello, Rossella

, p. 8345 - 8349 (1992)

One-electron-transfer processes, triggered by I- in catalytic amounts, convert methyl(trifluoromethyl)dioxirane (1) into 1,1,1-trifluoropropanone (trifluoroacetone) and dioxygen. It is proposed that the initially formed bis(oxy)methylene radical anion 1′ performs nucleophilic attack at the dioxirane 1, yielding a dimeric radical anion 2′; the latter then fragments into trifluoroacetone and superoxide ion (O2?-). The intermediacy of Superoxide ion (the propagator of the electron-transfer chain reaction) is demonstrated by its trapping with either benzoyl chloride or chlorotrimethylsilane. Also, potassium superoxide in catalytic amounts induces the fast and complete conversion of 1 into trifluoroacetone with evolution of dioxygen. The redox reaction between dioxirane 1 and iodide ion in acidic medium yields substantial amounts of hydrogen peroxide, which was detected by the catalase probe.



Paragraph 0053-0054; 0060-0061, (2021/03/19)

A method for oxidative cleavage of a compound with an unsaturated double bond is provided. The method comprises the following step: (A) providing a compound (I) with an unsaturated double bond, a reagent with trifluoromethyl, and a catalyst; wherein the catalyst is represented by the following formula (II): M(O)mL1yL2z (II); wherein, M, L1, L2, m, y, z, R1, R2 and R3 are defined in the specification; and (B) mixing the compound with an unsaturated double bond and the reagent with a trifluoromethyl to perform an oxidation of the compound with the unsaturated double bond by using the catalyst at air or an oxygen condition to get a compound presented as formula (III):



Paragraph 0071; 0076, (2021/07/10)

A method for oxidative cleavage of a compound with an unsaturated double bond is provided. The method includes the steps of: (A) providing a compound (I) with an unsaturated double bond, a trifluoromethyl-containing reagent, and a catalyst; wherein, the catalyst is represented by Formula (II): M(O)mL1yL2z??(II);wherein, M, L1, L2, m, y, z, R1, R2 and R3 are defined in the specification; and(B) mixing the compound with an unsaturated double bond and the trifluoromethyl-containing reagent to perform an oxidative cleavage of the compound with the unsaturated double bond by using the catalyst in air or under oxygen atmosphere condition to obtain a compound represented by Formula (III):

Catalytic conversion of ketones to esters: Via C(O)-C bond cleavage under transition-metal free conditions

Subaramanian, Murugan,Ramar, Palmurukan M.,Rana, Jagannath,Gupta, Virendra Kumar,Balaraman, Ekambaram

supporting information, p. 8143 - 8146 (2020/09/09)

The catalytic conversion of ketones to esters via C(O)-C bond cleavage under transition-metal free conditions is reported. This catalytic process proceeds under solvent-free conditions and offers an easy operational procedure, broad substrate scope with excellent selectivity, and reaction scalability. This journal is

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)


What can I do for you?
Get Best Price

Get Best Price for 421-50-1