1,4-anhydro-5,6-O-isopropylidene-2-O-p-methoxybenzoyl-D-sorbitol

Base Information

• Chemical Name: 1,4-anhydro-5,6-O-isopropylidene-2-O-p-methoxybenzoyl-D-sorbitol
• CAS No.: 1424709-66-9
• Molecular Formula: C₁₇H₂₂O₇
• Molecular Weight: 338.357
• Mol file: 1424709-66-9.mol

Synonyms:1,4-anhydro-5,6-O-isopropylidene-2-O-p-methoxybenzoyl-D-sorbitol

Chemical Property of 1,4-anhydro-5,6-O-isopropylidene-2-O-p-methoxybenzoyl-D-sorbitol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-anhydro-5,6-O-isopropylidene-2-O-p-methoxybenzoyl-D-sorbitol

There total 5 articles about 1,4-anhydro-5,6-O-isopropylidene-2-O-p-methoxybenzoyl-D-sorbitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1,4-anhydro-2-O-p-methoxybenzoyl-D-sorbitol (1424709-64-7) + 2,2-dimethoxy-propane (77-76-9) → 1,4-anhydro-5,6-O-isopropylidene-2-O-p-methoxybenzoyl-D-sorbitol (1424709-66-9)

Guidance literature:

With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 20 ℃; for 10h;

DOI:10.1002/ejoc.201201083

Reference yield:

1,4-anhydro-2-O-p-methoxybenzoyl-3,5,6-tri-O-orthoacetyl-D-sorbitol → 1,4-anhydro-5,6-O-isopropylidene-2-O-p-methoxybenzoyl-D-sorbitol (1424709-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Amberlite IR 120 H⁽¹⁺⁾ / methanol; water / 24 h / Reflux

2: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 10 h / 20 °C

With toluene-4-sulfonic acid; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201201083

Reference yield:

1,4-anhydro-D-glucitol (7726-97-8,10334-28-8,20662-31-1,22554-76-3,22554-77-4,22554-79-6,27299-12-3,28218-56-6,32742-35-1,40026-08-2,51196-40-8,51607-77-3,53648-56-9,96243-58-2,124379-08-4,124379-13-1) → 1,4-anhydro-5,6-O-isopropylidene-2-O-p-methoxybenzoyl-D-sorbitol (1424709-66-9)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 2 h

2: pyridine / 0 - 20 °C

3: Amberlite IR 120 H⁽¹⁺⁾ / methanol; water / 24 h / Reflux

4: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 10 h / 20 °C

With pyridine; toluene-4-sulfonic acid; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201201083

upstream raw materials:

4-methoxy-benzoyl chloride

1,4-anhydro-2-O-p-methoxybenzoyl-D-sorbitol

2,2-dimethoxy-propane

1,4-anhydro-D-glucitol