4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-leucinate

Base Information

Chemical Name:4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-leucinate
CAS No.:515871-95-1
Molecular Formula:C₃₂H₄₂F₂N₄O₈
Molecular Weight:648.704
Hs Code.:

Synonyms:4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-leucinate

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Chemical Property of 4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-leucinate

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Technology Process of 4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-leucinate

There total 4 articles about 4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-leucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 226087-02-1
4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenol

: 2-benzyloxycarbonylamino-2-difluoromethyl-4-methyl-pentanoic acid [1,2,3]triazolo[4,5-b]pyridin-3-yl ester

: 515871-95-1
4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-leucinate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 2.58333h;
DOI:10.1021/jo020613p

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 515871-95-1
4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-leucinate

Guidance literature:: Multi-step reaction with 3 steps

1: dioxane / 24 h / 20 °C / pH 7.0

2: tetrahydrofuran / 20 °C

3: 85 percent / n-butyllithium / tetrahydrofuran; hexane / 2.58 h / 20 °C

With n-butyllithium; In tetrahydrofuran; 1,4-dioxane; hexane;
DOI:10.1021/jo020613p

Reference yield:

: 322474-21-5
N,N'-bis-Boc-S-methyl-isothiourea

: 515871-95-1
4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(difluoromethyl)-D,L-leucinate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C

2: 85 percent / n-butyllithium / tetrahydrofuran; hexane / 2.58 h / 20 °C

With n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1021/jo020613p