(2S,5S,6E)-2,5-bis[3-(triisopropylsilyloxy)propyl]-1-[3-(4-benzyloxyphenyl)propionyl]-7-(o-nitrobenzenesulfonyl)-1,4,7-triazacycloundec-9-en-3-one

Base Information

• Chemical Name: (2S,5S,6E)-2,5-bis[3-(triisopropylsilyloxy)propyl]-1-[3-(4-benzyloxyphenyl)propionyl]-7-(o-nitrobenzenesulfonyl)-1,4,7-triazacycloundec-9-en-3-one
• CAS No.: 945492-99-9
• Molecular Formula: C₅₄H₈₄N₄O₉SSi₂
• Molecular Weight: 1021.52
• Mol file: 945492-99-9.mol

Synonyms:(2S,5S,6E)-2,5-bis[3-(triisopropylsilyloxy)propyl]-1-[3-(4-benzyloxyphenyl)propionyl]-7-(o-nitrobenzenesulfonyl)-1,4,7-triazacycloundec-9-en-3-one

Chemical Property of (2S,5S,6E)-2,5-bis[3-(triisopropylsilyloxy)propyl]-1-[3-(4-benzyloxyphenyl)propionyl]-7-(o-nitrobenzenesulfonyl)-1,4,7-triazacycloundec-9-en-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,5S,6E)-2,5-bis[3-(triisopropylsilyloxy)propyl]-1-[3-(4-benzyloxyphenyl)propionyl]-7-(o-nitrobenzenesulfonyl)-1,4,7-triazacycloundec-9-en-3-one

There total 19 articles about (2S,5S,6E)-2,5-bis[3-(triisopropylsilyloxy)propyl]-1-[3-(4-benzyloxyphenyl)propionyl]-7-(o-nitrobenzenesulfonyl)-1,4,7-triazacycloundec-9-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

(2R,S)-2-[N-allyl-3-(4-benzyloxyphenyl)propanamido]-N-[(2S)-1-(N-allyl-o-nitrophenylsulfonamido)-5-triisopropylsilyloxypentan-2-yl]-5-triisopropylsilyloxypentanamide (945492-93-3) → (2S,5S,6E)-2,5-bis[3-(triisopropylsilyloxy)propyl]-1-[3-(4-benzyloxyphenyl)propionyl]-7-(o-nitrobenzenesulfonyl)-1,4,7-triazacycloundec-9-en-3-one (945492-99-9) + (2R,5S,6E)-2,5-bis[3-(triisopropylsilyloxy)propyl]-1-[3-(4-benzyloxyphenyl)propionyl]-7-(o-nitrobenzenesulfonyl)-1,4,7-triazacycloundec-9-en-3-one (945493-00-5)

Guidance literature:

tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 40 ℃; for 12h;

DOI:10.1039/b702649h

Reference yield:

C16H27NO8 → (2S,5S,6E)-2,5-bis[3-(triisopropylsilyloxy)propyl]-1-[3-(4-benzyloxyphenyl)propionyl]-7-(o-nitrobenzenesulfonyl)-1,4,7-triazacycloundec-9-en-3-one (945492-99-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: NaBH₄ / methanol; tetrahydrofuran

2.1: triethylamine / dimethylformamide / 5 h / 20 °C

2.2: 6.46 g / DIBAL-H / tetrahydrofuran; toluene / 1 h / 0 °C

3.1: 61 percent / triphenylphosphine; DIAD / toluene; tetrahydrofuran / 3 h / 20 °C

4.1: TFA / CH₂Cl₂ / 1 h / 0 °C

5.1: 3.24 g / 1-hydroxy-7-azabenzotriazole; HATU; DIEA / dimethylformamide / 20 °C

6.1: 13 percent / Grubb's first generation catalyst / CH₂Cl₂ / 12 h / 40 °C

With sodium tetrahydroborate; 1-hydroxy-7-aza-benzotriazole; di-isopropyl azodicarboxylate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; Grubbs catalyst first generation; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 3.1: Mitsunobu reaction;

DOI:10.1039/b702649h

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → (2S,5S,6E)-2,5-bis[3-(triisopropylsilyloxy)propyl]-1-[3-(4-benzyloxyphenyl)propionyl]-7-(o-nitrobenzenesulfonyl)-1,4,7-triazacycloundec-9-en-3-one (945492-99-9)

Guidance literature:

Multi-step reaction with 11 steps

1.1: H₂SO₄

1.2: pyridine / ethanol

2.1: triethylamine / dimethylformamide

3.1: potassium carbonate / dimethylformamide

4.1: 42 g / H₂ / Pd/C / ethanol

5.1: triethylamine

6.1: NaBH₄ / methanol; tetrahydrofuran

7.1: triethylamine / dimethylformamide / 5 h / 20 °C

7.2: 6.46 g / DIBAL-H / tetrahydrofuran; toluene / 1 h / 0 °C

8.1: 61 percent / triphenylphosphine; DIAD / toluene; tetrahydrofuran / 3 h / 20 °C

9.1: TFA / CH₂Cl₂ / 1 h / 0 °C

10.1: 3.24 g / 1-hydroxy-7-azabenzotriazole; HATU; DIEA / dimethylformamide / 20 °C

11.1: 13 percent / Grubb's first generation catalyst / CH₂Cl₂ / 12 h / 40 °C

With sodium tetrahydroborate; 1-hydroxy-7-aza-benzotriazole; di-isopropyl azodicarboxylate; sulfuric acid; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; Grubbs catalyst first generation; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 8.1: Mitsunobu reaction;

DOI:10.1039/b702649h

upstream raw materials:

(2R,S)-2-[N-allyl-3-(4-benzyloxyphenyl)propanamido]-N-[(2S)-1-(N-allyl-o-nitrophenylsulfonamido)-5-triisopropylsilyloxypentan-2-yl]-5-triisopropylsilyloxypentanamide

(S)-2-(N-Boc-amino)-5-(triisopropylsilyloxy)pentan-1-ol

C₂₃H₄₁N₃O₅SSi

methyl (S)-2-(N-allylamino)-5-(triisopropylsilyloxy)pentanoate

Downstream raw materials:

(2S,5S,6E)-2,5-bis[3-(triisopropylsilyloxy)propyl]-1-[3-(4-benzyloxyphenyl)propionyl]-7-(2-naphthylacetyl)-1,4,7-triazacycloundec-9-en-3-one

(2S,5S,6E)-2,5-bis(3-hydroxypropyl)-1-[3-(4-benzyloxyphenyl)propionyl]-7-(2-naphthylacetyl)-1,4,7-triazacycloundec-9-en-3-one

Triphenylphosphine oxide