(2S,5S,6E)-2,5-bis(3-hydroxypropyl)-1-[3-(4-benzyloxyphenyl)propionyl]-7-(2-naphthylacetyl)-1,4,7-triazacycloundec-9-en-3-one

Base Information

Chemical Name:(2S,5S,6E)-2,5-bis(3-hydroxypropyl)-1-[3-(4-benzyloxyphenyl)propionyl]-7-(2-naphthylacetyl)-1,4,7-triazacycloundec-9-en-3-one
CAS No.:945493-15-2
Molecular Formula:C₄₂H₄₉N₃O₆
Molecular Weight:691.868
Hs Code.:

Synonyms:(2S,5S,6E)-2,5-bis(3-hydroxypropyl)-1-[3-(4-benzyloxyphenyl)propionyl]-7-(2-naphthylacetyl)-1,4,7-triazacycloundec-9-en-3-one

Suppliers and Price of (2S,5S,6E)-2,5-bis(3-hydroxypropyl)-1-[3-(4-benzyloxyphenyl)propionyl]-7-(2-naphthylacetyl)-1,4,7-triazacycloundec-9-en-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,5S,6E)-2,5-bis(3-hydroxypropyl)-1-[3-(4-benzyloxyphenyl)propionyl]-7-(2-naphthylacetyl)-1,4,7-triazacycloundec-9-en-3-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,5S,6E)-2,5-bis(3-hydroxypropyl)-1-[3-(4-benzyloxyphenyl)propionyl]-7-(2-naphthylacetyl)-1,4,7-triazacycloundec-9-en-3-one

There total 18 articles about (2S,5S,6E)-2,5-bis(3-hydroxypropyl)-1-[3-(4-benzyloxyphenyl)propionyl]-7-(2-naphthylacetyl)-1,4,7-triazacycloundec-9-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 945493-07-2
(2S,5S,6E)-2,5-bis[3-(triisopropylsilyloxy)propyl]-1-[3-(4-benzyloxyphenyl)propionyl]-7-(2-naphthylacetyl)-1,4,7-triazacycloundec-9-en-3-one

: 945493-15-2
(2S,5S,6E)-2,5-bis(3-hydroxypropyl)-1-[3-(4-benzyloxyphenyl)propionyl]-7-(2-naphthylacetyl)-1,4,7-triazacycloundec-9-en-3-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -20 ℃; for 96h;
DOI:10.1039/b702649h

Reference yield:

: C₁₆H₂₇NO₈

: 945493-15-2
(2S,5S,6E)-2,5-bis(3-hydroxypropyl)-1-[3-(4-benzyloxyphenyl)propionyl]-7-(2-naphthylacetyl)-1,4,7-triazacycloundec-9-en-3-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: NaBH₄ / methanol; tetrahydrofuran

2.1: triethylamine / dimethylformamide / 5 h / 20 °C

2.2: 6.46 g / DIBAL-H / tetrahydrofuran; toluene / 1 h / 0 °C

3.1: 61 percent / triphenylphosphine; DIAD / toluene; tetrahydrofuran / 3 h / 20 °C

4.1: TFA / CH₂Cl₂ / 1 h / 0 °C

5.1: 3.24 g / 1-hydroxy-7-azabenzotriazole; HATU; DIEA / dimethylformamide / 20 °C

6.1: 13 percent / Grubb's first generation catalyst / CH₂Cl₂ / 12 h / 40 °C

7.1: mercaptoacetic acid; LiOH*H₂O / dimethylformamide / 1 h / 20 °C

8.1: 382 mg / HATU; triethylamine / dimethylformamide / 20 °C

9.1: 78 percent / tetrabutylammonium fluoride / tetrahydrofuran / 96 h / -20 °C

With lithium hydroxide; sodium tetrahydroborate; 1-hydroxy-7-aza-benzotriazole; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; mercaptoacetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; Grubbs catalyst first generation; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 3.1: Mitsunobu reaction;
DOI:10.1039/b702649h

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 945493-15-2
(2S,5S,6E)-2,5-bis(3-hydroxypropyl)-1-[3-(4-benzyloxyphenyl)propionyl]-7-(2-naphthylacetyl)-1,4,7-triazacycloundec-9-en-3-one

Guidance literature:: Multi-step reaction with 14 steps

1.1: H₂SO₄

1.2: pyridine / ethanol

2.1: triethylamine / dimethylformamide

3.1: potassium carbonate / dimethylformamide

4.1: 42 g / H₂ / Pd/C / ethanol

5.1: triethylamine

6.1: NaBH₄ / methanol; tetrahydrofuran

7.1: triethylamine / dimethylformamide / 5 h / 20 °C

7.2: 6.46 g / DIBAL-H / tetrahydrofuran; toluene / 1 h / 0 °C

8.1: 61 percent / triphenylphosphine; DIAD / toluene; tetrahydrofuran / 3 h / 20 °C

9.1: TFA / CH₂Cl₂ / 1 h / 0 °C

10.1: 3.24 g / 1-hydroxy-7-azabenzotriazole; HATU; DIEA / dimethylformamide / 20 °C

11.1: 13 percent / Grubb's first generation catalyst / CH₂Cl₂ / 12 h / 40 °C

12.1: mercaptoacetic acid; LiOH*H₂O / dimethylformamide / 1 h / 20 °C

13.1: 382 mg / HATU; triethylamine / dimethylformamide / 20 °C

14.1: 78 percent / tetrabutylammonium fluoride / tetrahydrofuran / 96 h / -20 °C

With lithium hydroxide; sodium tetrahydroborate; 1-hydroxy-7-aza-benzotriazole; di-isopropyl azodicarboxylate; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; mercaptoacetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; Grubbs catalyst first generation; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 8.1: Mitsunobu reaction;
DOI:10.1039/b702649h