N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide

Base Information

• Chemical Name: N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide
• CAS No.: 1394165-26-4
• Molecular Formula: C₃₈H₃₂F₃N₅O₅
• Molecular Weight: 695.698
• Mol file: 1394165-26-4.mol

Synonyms:N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide

Chemical Property of N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide

There total 16 articles about N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)aniline (1394166-11-0) + C15H7ClF2N2O2 → N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide (1394165-26-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 10h; Cooling with ice;

DOI:10.1016/j.bmc.2013.04.013

Reference yield:

1-(3,4-difluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid (1436418-25-5) → N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide (1394165-26-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 5 h / 80 °C

2: triethylamine / dichloromethane / 10 h / 20 °C / Cooling with ice

With thionyl chloride; triethylamine; In dichloromethane; toluene;

DOI:10.1016/j.bmc.2013.04.013

Reference yield:

(Ε)-1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one (1394166-08-5) → N-(3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3,4-difluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide (1394165-26-4)

Guidance literature:

Multi-step reaction with 6 steps

1: acetic acid / 2 h / 60 - 80 °C

2: acetonitrile / 10 h / 85 °C

3: trichlorophosphate / acetonitrile / 6 h / 85 °C

4: chlorobenzene / 30 h / 140 °C

5: ammonium chloride; iron / ethanol; water / 5 h / Reflux

6: triethylamine / dichloromethane / 10 h / 20 °C / Cooling with ice

With iron; ammonium chloride; triethylamine; trichlorophosphate; In ethanol; dichloromethane; water; acetic acid; chlorobenzene; acetonitrile;

DOI:10.1016/j.bmc.2013.04.013

upstream raw materials:

1-(3,4-difluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid

1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one

(Ε)-1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one

o-fluoro-benzoic acid