6-(3-fluoro-4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone

Base Information

• Chemical Name: 6-(3-fluoro-4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone
• CAS No.: 52239-97-1
• Molecular Formula: C₁₁H₁₁FN₂O₂
• Molecular Weight: 222.219
• Mol file: 52239-97-1.mol

Synonyms:6-(3-fluoro-4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone

Chemical Property of 6-(3-fluoro-4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(3-fluoro-4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone

There total 4 articles about 6-(3-fluoro-4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

γ-(3-fluoro-4-methoxy)-γ-oxobenzenebutanoic acid (347-63-7) → 6-(3-fluoro-4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone (52239-97-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) + 1-(3-fluoro-4-methoxyphenyl)ethanone (455-91-4) → 6-(3-fluoro-4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone (52239-97-1)

Guidance literature:

1-(3-fluoro-4-methoxyphenyl)ethanone; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

1-fluoro-2-methoxybenzene (321-28-8) → 6-(3-fluoro-4-methoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone (52239-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride; carbon disulfide / 4 h / 40 - 50 °C

2: hydrazine hydrate / ethanol / Reflux

With carbon disulfide; aluminum (III) chloride; hydrazine hydrate; In ethanol;

DOI:10.1080/14756366.2020.1755670

upstream raw materials:

γ-(3-fluoro-4-methoxy)-γ-oxobenzenebutanoic acid

bromoacetic acid tert-butyl ester

1-(3-fluoro-4-methoxyphenyl)ethanone

1-fluoro-2-methoxybenzene

Downstream raw materials:

6-(3-fluoro-4-hydroxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one