(αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one

Base Information

Chemical Name:(αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one
CAS No.:175777-31-8
Molecular Formula:C₁₈H₁₉NO₂
Molecular Weight:281.354
Hs Code.:

Synonyms:(αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one

Chemical Property:

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Technology Process of (αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one

There total 1 articles about (αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 175659-77-5
(αR)-N-[2-hydroxy-1-phenylethyl]-1,4-dihydro-2H-isoquinolin-3-one

: 74-88-4
methyl iodide

: 2-((R)-2-Hydroxy-1-phenyl-ethyl)-4,4-dimethyl-1,4-dihydro-2H-isoquinolin-3-one

: 175777-31-8
(αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 3h;
DOI:10.1016/S0040-4020(98)00491-8

Reference yield: 100.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 175777-31-8
(αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one

: (αR,4S)-[2-(4-tert-butoxycarbonylmethyl-4-methyl-3-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-2-phenylethoxy]acetic acid ter-butyl ester

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃; for 18h;
DOI:10.1016/S0040-4020(98)00491-8

Reference yield: 65.0%

: 10297-05-9
1-chloro 4-iodobutane

: 175777-31-8
(αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one

: 213821-81-9
(αR,4S)-4-(4-chlorobutyl)-N-(2-hydroxy-1-phenylethyl)-4-methyl-1,4-dihydro-2H-isoquinolin-3-one

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/S0040-4020(98)00491-8