Technology Process of (S)-methyl 2-amino-3-(3,4,5-trimethoxyphenyl)propanoate
There total 8 articles about (S)-methyl 2-amino-3-(3,4,5-trimethoxyphenyl)propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium on activated charcoal; hydrogen;
In
methanol;
at 45 ℃;
for 6h;
under 760.051 Torr;
DOI:10.1016/j.tet.2020.131243
- Guidance literature:
-
Multi-step reaction with 8 steps
1: bromine; acetic acid
3: hydrogenchloride / 1,4-dioxane
4: N-ethyl-N,N-diisopropylamine; potassium carbonate / acetonitrile / 24 h / Reflux
5: lithium hydroxide monohydrate; water / tetrahydrofuran / 65 - 70 °C
6: lithium hydroxide monohydrate; water; copper acetylacetonate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide / dimethyl sulfoxide / 24 h / 110 - 115 °C / Inert atmosphere
7: potassium carbonate / acetonitrile / 3 h / 65 - 70 °C
8: palladium on activated charcoal; hydrogen / methanol / 6 h / 45 °C / 760.05 Torr
With
hydrogenchloride; copper acetylacetonate; lithium hydroxide monohydrate; palladium on activated charcoal; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; water; hydrogen; bromine; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.tet.2020.131243
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium hydroxide monohydrate; water / tetrahydrofuran / 65 - 70 °C
2: lithium hydroxide monohydrate; water; copper acetylacetonate; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide / dimethyl sulfoxide / 24 h / 110 - 115 °C / Inert atmosphere
3: potassium carbonate / acetonitrile / 3 h / 65 - 70 °C
4: palladium on activated charcoal; hydrogen / methanol / 6 h / 45 °C / 760.05 Torr
With
copper acetylacetonate; lithium hydroxide monohydrate; palladium on activated charcoal; N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide; water; hydrogen; potassium carbonate;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.tet.2020.131243
