trans-2-(2-(1-4-(N-tert-butyloxycarbonyl)amino)cyclohexyl)ethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:trans-2-(2-(1-4-(N-tert-butyloxycarbonyl)amino)cyclohexyl)ethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline
CAS No.:215790-43-5
Molecular Formula:C₂₃H₃₃N₃O₂
Molecular Weight:383.534
Hs Code.:

Synonyms:trans-2-(2-(1-4-(N-tert-butyloxycarbonyl)amino)cyclohexyl)ethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of trans-2-(2-(1-4-(N-tert-butyloxycarbonyl)amino)cyclohexyl)ethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline

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Technology Process of trans-2-(2-(1-4-(N-tert-butyloxycarbonyl)amino)cyclohexyl)ethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline

There total 10 articles about trans-2-(2-(1-4-(N-tert-butyloxycarbonyl)amino)cyclohexyl)ethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 215790-29-7
trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetaldehyde

: 215790-43-5
trans-2-(2-(1-4-(N-tert-butyloxycarbonyl)amino)cyclohexyl)ethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;
DOI:10.1021/acs.jmedchem.8b00192

Reference yield: 56.0%

: 149355-52-2
7-cyano-1,2,3,4-tetrahydroisoquinoline

: 215790-29-7
trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetaldehyde

: 215790-43-5
trans-2-(2-(1-4-(N-tert-butyloxycarbonyl)amino)cyclohexyl)ethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;
DOI:10.1021/jm401318w

Reference yield:

: 61502-37-2
trans-(4-amino)-cyclohexylacetic acid hydrogen sulfate

: 215790-43-5
trans-2-(2-(1-4-(N-tert-butyloxycarbonyl)amino)cyclohexyl)ethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: H₂SO₄ / 5 h / Heating

2: Et₃N / CH₂Cl₂ / 18 h / 20 °C

3: diisobutylaluminum hydride / toluene / 0.3 h / -78 °C

4: NaBH(OAc)3 / 1,2-dichloro-ethane / 16 h / 20 °C

With sulfuric acid; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; triethylamine; In dichloromethane; 1,2-dichloro-ethane; toluene; 1: Esterification / 2: Acylation / 3: Reduction / 4: reductive amination;
DOI:10.1021/jm000090i