(2R,6S)-1-(Benzyl-trimethylsilanylmethyl-amino)-6-((S)-1-hydroxy-propyl)-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

Base Information

Chemical Name:(2R,6S)-1-(Benzyl-trimethylsilanylmethyl-amino)-6-((S)-1-hydroxy-propyl)-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide
CAS No.:816452-90-1
Molecular Formula:C₂₈H₄₁N₃O₂Si
Molecular Weight:479.738
Hs Code.:

Synonyms:(2R,6S)-1-(Benzyl-trimethylsilanylmethyl-amino)-6-((S)-1-hydroxy-propyl)-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

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Chemical Property of (2R,6S)-1-(Benzyl-trimethylsilanylmethyl-amino)-6-((S)-1-hydroxy-propyl)-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

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Technology Process of (2R,6S)-1-(Benzyl-trimethylsilanylmethyl-amino)-6-((S)-1-hydroxy-propyl)-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

There total 7 articles about (2R,6S)-1-(Benzyl-trimethylsilanylmethyl-amino)-6-((S)-1-hydroxy-propyl)-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-((R)-1-Phenyl-ethyl)-isothiazol-3-one

: 816452-90-1
(2R,6S)-1-(Benzyl-trimethylsilanylmethyl-amino)-6-((S)-1-hydroxy-propyl)-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3.8 g / m-chloroperoxybenzoic acid / CH₂Cl₂ / 3 h / 0 °C

2.1: toluene / 70 h / 80 °C

2.2: 50 percent / NaHCO₃ / H₂O; toluene / 0.5 h / 20 °C

3.1: NaOH / acetone; H₂O / 6.5 h / 0 - 20 °C

4.1: CHCl₃ / 14 h / Heating

With sodium hydroxide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform; water; acetone; toluene;
DOI:10.1021/jo048581o

Reference yield:

: 1026552-54-4
C₁₁H₁₈N₂OSi

: 816452-90-1
(2R,6S)-1-(Benzyl-trimethylsilanylmethyl-amino)-6-((S)-1-hydroxy-propyl)-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: LiAlH₄ / diethyl ether / 4 h / 0 - 20 °C

2.1: MgSO₄ / CH₂Cl₂ / 2 h / 40 °C

3.1: toluene / 70 h / 80 °C

3.2: 50 percent / NaHCO₃ / H₂O; toluene / 0.5 h / 20 °C

4.1: NaOH / acetone; H₂O / 6.5 h / 0 - 20 °C

5.1: CHCl₃ / 14 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; magnesium sulfate; In diethyl ether; dichloromethane; chloroform; water; acetone; toluene;
DOI:10.1021/jo048581o

Reference yield:

: 816452-88-7
N-benzyl-N-trimethylsilanylmethyl-hydrazine

: 816452-90-1
(2R,6S)-1-(Benzyl-trimethylsilanylmethyl-amino)-6-((S)-1-hydroxy-propyl)-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: MgSO₄ / CH₂Cl₂ / 2 h / 40 °C

2.1: toluene / 70 h / 80 °C

2.2: 50 percent / NaHCO₃ / H₂O; toluene / 0.5 h / 20 °C

3.1: NaOH / acetone; H₂O / 6.5 h / 0 - 20 °C

4.1: CHCl₃ / 14 h / Heating

With sodium hydroxide; magnesium sulfate; In dichloromethane; chloroform; water; acetone; toluene;
DOI:10.1021/jo048581o