3H-Oxazolo[3,4-a]pyridine-5-carboxylicacid,1-ethyl-1,5,8,8a-tetrahydro-3-oxo-,(1S,5S,8aS)-(9CI)

Base Information

Chemical Name:3H-Oxazolo[3,4-a]pyridine-5-carboxylicacid,1-ethyl-1,5,8,8a-tetrahydro-3-oxo-,(1S,5S,8aS)-(9CI)
CAS No.:816453-12-0
Molecular Formula:C₁₀H₁₃NO₄
Molecular Weight:211.218
Hs Code.:
Mol file:816453-12-0.mol

Synonyms:3H-Oxazolo[3,4-a]pyridine-5-carboxylicacid,1-ethyl-1,5,8,8a-tetrahydro-3-oxo-,(1S,5S,8aS)-(9CI)

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Chemical Property of 3H-Oxazolo[3,4-a]pyridine-5-carboxylicacid,1-ethyl-1,5,8,8a-tetrahydro-3-oxo-,(1S,5S,8aS)-(9CI)

Chemical Property:

Boiling Point:465.7±45.0 °C(Predicted)
PKA:3.70±0.40(Predicted)
Density:1.35±0.1 g/cm3(Predicted)

Purity/Quality:

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Technology Process of 3H-Oxazolo[3,4-a]pyridine-5-carboxylicacid,1-ethyl-1,5,8,8a-tetrahydro-3-oxo-,(1S,5S,8aS)-(9CI)

There total 6 articles about 3H-Oxazolo[3,4-a]pyridine-5-carboxylicacid,1-ethyl-1,5,8,8a-tetrahydro-3-oxo-,(1S,5S,8aS)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026913-82-5
C₁₈H₂₁N₃O₄

: 816453-12-0
(1S,8aS)-1-Ethyl-3-oxo-1,5,8,8a-tetrahydro-oxazolo[3,4-a]pyridine-5-carboxylic acid

Guidance literature:: With barium dihydroxide; In tetrahydrofuran; at -10 ℃; for 16h;
DOI:10.1021/jo048581o

Reference yield:

: 700380-12-7
(2R,6S)-6-((S)-1-Hydroxy-propyl)-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid ((R)-1-phenyl-ethyl)-amide

: 816453-12-0
(1S,8aS)-1-Ethyl-3-oxo-1,5,8,8a-tetrahydro-oxazolo[3,4-a]pyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / CH₂Cl₂ / 15 h / 20 °C

2: sodium nitrite; acetic acid; acetic anhydride / 3 h / 0 - 20 °C

3: 0.13 g / Ba(OH)2 / tetrahydrofuran / 16 h / -10 °C

With barium dihydroxide; acetic anhydride; acetic acid; sodium nitrite; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo048581o

Reference yield:

: 816453-11-9
(1S,5R,8aS)-1-Ethyl-3-oxo-1,5,8,8a-tetrahydro-oxazolo[3,4-a]pyridine-5-carboxylic acid ((R)-1-phenyl-ethyl)-amide

: 816453-12-0
(1S,8aS)-1-Ethyl-3-oxo-1,5,8,8a-tetrahydro-oxazolo[3,4-a]pyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium nitrite; acetic acid; acetic anhydride / 3 h / 0 - 20 °C

2: 0.13 g / Ba(OH)2 / tetrahydrofuran / 16 h / -10 °C

With barium dihydroxide; acetic anhydride; acetic acid; sodium nitrite; In tetrahydrofuran;
DOI:10.1021/jo048581o