(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)-acetic acid

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Chemical Name:(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)-acetic acid
CAS No.:1233361-56-2
Molecular Formula:C₂₁H₁₈N₆O₄
Molecular Weight:418.412
Hs Code.:

Synonyms:(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)-acetic acid

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Chemical Property of (2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)-acetic acid

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Technology Process of (2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)-acetic acid

There total 9 articles about (2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1233361-55-1
(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)acetic acid methyl ester

: 1233361-56-2
(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)-acetic acid

Guidance literature:: (2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)acetic acid methyl ester; With water; lithium hydroxide; In methanol; at 20 ℃; for 1h;

With hydrogenchloride; In methanol; water; pH=3;

Reference yield:

: 87199-15-3
[3-(hydroxymethyl)phenyl]boronic acid

: 1233361-56-2
(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium phosphate tribasic trihydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

2.1: thionyl chloride / dichloromethane / 3 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

4.1: potassium acetate / N,N-dimethyl-formamide / 0.25 h / 70 °C / Inert atmosphere

4.2: 18 h / 70 °C / Inert atmosphere

5.1: water / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

5.2: pH 1

6.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: water; lithium hydroxide / methanol / 1 h / 20 °C

7.2: pH 3

With thionyl chloride; potassium phosphate tribasic trihydrate; water; potassium acetate; caesium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1100598-44-4
2-[3-(5-hydroxypyrimidin-2-yl)benzyl]-6-(1-methyl-1H-pyrazol-4-yl)-2H-pyridazin-3-one

: 1233361-56-2
(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: water; lithium hydroxide / methanol / 1 h / 20 °C

2.2: pH 3

With water; caesium carbonate; lithium hydroxide; In methanol; N,N-dimethyl-formamide;