3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine

Base Information

• Chemical Name: 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine
• CAS No.: 943541-20-6
• Molecular Formula: C8H7ClN4
• Molecular Weight: 194.62
• Hs Code.: 2933990090
• Mol file: 943541-20-6.mol

Synonyms:3-chloro-6-(1-methylpyrazol-4-yl)pyridazine;

Chemical Property of 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine

Chemical Property:

• PSA: 43.60000
• LogP: 1.53050
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine ^*data from reagent suppliers

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Technology Process of 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine

There total 7 articles about 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-chloro-6-(1H-pyrazol-4-yl)pyridazine (1211519-08-2) + isopropyl bromide (75-26-3) + methyl iodide (74-88-4) → 3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine (943541-20-6)

Guidance literature:

3-chloro-6-(1H-pyrazol-4-yl)pyridazine; isopropyl bromide; With 18-crown-6 ether; potassium tert-butylate; In diethyl ether; at 20 ℃; for 0.333333h;

methyl iodide; In diethyl ether; at 0 - 20 ℃;

Reference yield: 82.0%

3-chloro-6-iodopyridazine (135034-10-5) + 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (761446-44-0) → 3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine (943541-20-6)

Guidance literature:

With potassium phosphate; N-benzyl-N,N,N-triethylammonium chloride; triphenylphosphine; palladium diacetate; In tetrahydrofuran; water; at 65 ℃; for 16h;

Reference yield: 76.0%

3,6-dichlorpyridazine (141-30-0) + 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (761446-44-0) → 3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine (943541-20-6)

Guidance literature:

With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 80 ℃; for 4h;

upstream raw materials:

3,6-dichlorpyridazine

1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

3-chloro-6-iodopyridazine

3-chloro-6-(1-trityl-1H-pyrazol-4-yl)pyridazine

Downstream raw materials:

JNJ-38877605

6-(1-methyl-1H-pyrazol-4-yl)-3-(2-methyl-2H-indazol-5-ylthio)-[1,2,4]triazolo[4,3-b]pyridazine

N-ethyl-2-(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)acetamide

(2-{3-[3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yloxy)acetyl chloride

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