4-(3-(2-aminopyrimidin-4-yl)-1H-indol-5-yl)-6-(cyclohexyloxy)pyrimidin-2-amine

Base Information

Chemical Name:4-(3-(2-aminopyrimidin-4-yl)-1H-indol-5-yl)-6-(cyclohexyloxy)pyrimidin-2-amine
CAS No.:1638286-19-7
Molecular Formula:C₂₂H₂₃N₇O
Molecular Weight:401.471
Hs Code.:

Synonyms:4-(3-(2-aminopyrimidin-4-yl)-1H-indol-5-yl)-6-(cyclohexyloxy)pyrimidin-2-amine

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Chemical Property of 4-(3-(2-aminopyrimidin-4-yl)-1H-indol-5-yl)-6-(cyclohexyloxy)pyrimidin-2-amine

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Technology Process of 4-(3-(2-aminopyrimidin-4-yl)-1H-indol-5-yl)-6-(cyclohexyloxy)pyrimidin-2-amine

There total 7 articles about 4-(3-(2-aminopyrimidin-4-yl)-1H-indol-5-yl)-6-(cyclohexyloxy)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 593-85-1,90332-86-8,3425-08-9
guanidine carbonate

: 1638286-05-1
C₃₀H₃₃N₅O₄S

: 1638286-19-7
4-(3-(2-aminopyrimidin-4-yl)-1H-indol-5-yl)-6-(cyclohexyloxy)pyrimidin-2-amine

Guidance literature:: With potassium carbonate; In 2-methoxy-ethanol; at 150 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;
DOI:10.5012/bkcs.2014.35.7.2123

Reference yield:

: 108-93-0
cyclohexanol

: 1638286-19-7
4-(3-(2-aminopyrimidin-4-yl)-1H-indol-5-yl)-6-(cyclohexyloxy)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / 0.17 h / Microwave irradiation

2: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; ethanol; water / 0.17 h / 110 °C / Inert atmosphere; Microwave irradiation

3: potassium carbonate / 2-methoxy-ethanol / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; sodium hydride; potassium carbonate; In 1,4-dioxane; ethanol; 2-methoxy-ethanol; water; 2: |Suzuki Coupling;
DOI:10.5012/bkcs.2014.35.7.2123

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1638286-19-7
4-(3-(2-aminopyrimidin-4-yl)-1H-indol-5-yl)-6-(cyclohexyloxy)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2: aluminum (III) chloride; carbon disulfide / Inert atmosphere

3: N,N-dimethyl-formamide / Microwave irradiation

4: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.17 h / 110 °C / Inert atmosphere; Microwave irradiation

5: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; ethanol; water / 0.17 h / 110 °C / Inert atmosphere; Microwave irradiation

6: potassium carbonate / 2-methoxy-ethanol / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

With carbon disulfide; aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium hydride; potassium carbonate; In 1,4-dioxane; ethanol; 2-methoxy-ethanol; water; N,N-dimethyl-formamide; 2: |Friedel-Crafts Acylation / 4: |Miyaura Borylation Reaction / 5: |Suzuki Coupling;
DOI:10.5012/bkcs.2014.35.7.2123