3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Base Information

Chemical Name:3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester
CAS No.:1359823-71-4
Molecular Formula:C₂₉H₃₂F₅N₃O₈
Molecular Weight:645.58
Hs Code.:

Synonyms:3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

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Chemical Property of 3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

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Technology Process of 3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

There total 12 articles about 3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1359823-70-3
3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

: 1359823-71-4
3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 315688-09-6
3-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

: 1359823-71-4
3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 0.5 h

3.1: HATU / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 °C

4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; hydrogen; HATU; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 769-39-1,85303-67-9
2,3,5,6-tetraflourophenol

: 1359823-71-4
3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium fluoride / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 0.5 h

4.1: HATU / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 20 °C

5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

With potassium fluoride; sodium tetrahydroborate; hydrogen; HATU; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;