3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

Base Information

Chemical Name:3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
CAS No.:1359823-69-0
Molecular Formula:C₂₅H₂₄F₅N₃O₈
Molecular Weight:589.473
Hs Code.:

Synonyms:3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

Suppliers and Price of 3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

There total 13 articles about 3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1359823-71-4
3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

: 1359823-69-0
3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 315688-10-9
3-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

: 1359823-69-0
3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 0.5 h

2.1: HATU / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 20 °C

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With hydrogen; HATU; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium 10% on activated carbon; In ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 315688-09-6
3-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

: 1359823-69-0
3-{2-[((4-fluoromethoxy)phenylaminooxalyl)amino]-3-methylbutyrylamino}-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 0.5 h

3.1: HATU / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 °C

4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; hydrogen; HATU; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide;