Technology Process of [(1S,6R,8aR)-1-(tert-Butyl-dimethyl-silanyloxy)-3-oxo-octahydro-indolizin-6-yl]-carbamic acid benzyl ester
There total 10 articles about [(1S,6R,8aR)-1-(tert-Butyl-dimethyl-silanyloxy)-3-oxo-octahydro-indolizin-6-yl]-carbamic acid benzyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 75 percent / imidazole / dimethylformamide / 1 h / Ambient temperature
2: Cs2CO3 / tetrahydrofuran / 15 h / Ambient temperature
3: pyridine / 5 h
4: 57 percent / 1,2-dichloro-benzene / 4 h / Heating
5: 99 percent / H2 / 10percent Pd/C / methanol / 4 h / 1 Torr
6: KOH / methanol; H2O / 1 h / Ambient temperature
7: 1.) pyridine, ethyl chloroformate, 2.) NaN3 / 1.) THF, 1 h, 2.) H2O, 0 deg C, 1 h
8: tetrahydrofuran / 4 h / Heating
9: 12 h / Ambient temperature
With
pyridine; 1H-imidazole; potassium hydroxide; sodium azide; hydrogen; chloroformic acid ethyl ester; caesium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 1,2-dichloro-benzene;
DOI:10.1021/ja00389a030
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 75 percent / imidazole / dimethylformamide / 1 h / Ambient temperature
2: Cs2CO3 / tetrahydrofuran / 15 h / Ambient temperature
3: pyridine / 5 h
4: 57 percent / 1,2-dichloro-benzene / 4 h / Heating
5: 99 percent / H2 / 10percent Pd/C / methanol / 4 h / 1 Torr
6: KOH / methanol; H2O / 1 h / Ambient temperature
7: 1.) pyridine, ethyl chloroformate, 2.) NaN3 / 1.) THF, 1 h, 2.) H2O, 0 deg C, 1 h
8: tetrahydrofuran / 4 h / Heating
9: 12 h / Ambient temperature
With
pyridine; 1H-imidazole; potassium hydroxide; sodium azide; hydrogen; chloroformic acid ethyl ester; caesium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 1,2-dichloro-benzene;
DOI:10.1021/ja00389a030
- Guidance literature:
-
Multi-step reaction with 8 steps
1: Cs2CO3 / tetrahydrofuran / 15 h / Ambient temperature
2: pyridine / 5 h
3: 57 percent / 1,2-dichloro-benzene / 4 h / Heating
4: 99 percent / H2 / 10percent Pd/C / methanol / 4 h / 1 Torr
5: KOH / methanol; H2O / 1 h / Ambient temperature
6: 1.) pyridine, ethyl chloroformate, 2.) NaN3 / 1.) THF, 1 h, 2.) H2O, 0 deg C, 1 h
7: tetrahydrofuran / 4 h / Heating
8: 12 h / Ambient temperature
With
pyridine; potassium hydroxide; sodium azide; hydrogen; chloroformic acid ethyl ester; caesium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; water; 1,2-dichloro-benzene;
DOI:10.1021/ja00389a030
