Chas-DPhe(p-NH₂)-Phe(p-NH₂)-OMe

Base Information

Chemical Name:Chas-DPhe(p-NH₂)-Phe(p-NH₂)-OMe
CAS No.:1417628-92-2
Molecular Formula:C₂₅H₃₅N₅O₅S
Molecular Weight:517.649
Hs Code.:

Chas-DPhe(p-NH<SUB>2</SUB>)-Phe(p-NH<SUB>2</SUB>)-OMe

Synonyms:Chas-DPhe(p-NH₂)-Phe(p-NH₂)-OMe

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Chemical Property of Chas-DPhe(p-NH₂)-Phe(p-NH₂)-OMe

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Technology Process of Chas-DPhe(p-NH₂)-Phe(p-NH₂)-OMe

There total 4 articles about Chas-DPhe(p-NH₂)-Phe(p-NH₂)-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.7%

: 1417628-91-1
Chas-DPhe(p-NO₂)-Phe(p-NO₂)-OMe

: 1417628-92-2
Chas-DPhe(p-NH₂)-Phe(p-NH₂)-OMe

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In acetic acid; at 20 ℃;
DOI:10.1021/acs.jmedchem.6b00606

Reference yield:

: 10314-35-9
cyclohexylsulfamoyl chloride

: 1417628-92-2
Chas-DPhe(p-NH₂)-Phe(p-NH₂)-OMe

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; chloro-trimethyl-silane / dichloromethane / 1 h / Reflux

1.2: 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 0 °C

3.1: palladium on activated charcoal; hydrogen; acetic acid

With chloro-trimethyl-silane; palladium on activated charcoal; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1417628-90-0
Chas-D-Phe(4-NO₂)-OH

: 1417628-92-2
Chas-DPhe(p-NH₂)-Phe(p-NH₂)-OMe

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 0 °C

2: palladium on activated charcoal; hydrogen; acetic acid

With palladium on activated charcoal; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;