carbonic acid 8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl ester methyl ester

Base Information

Chemical Name:carbonic acid 8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl ester methyl ester
CAS No.:1227165-17-4
Molecular Formula:C₁₇H₁₅ClN₂O₃
Molecular Weight:330.771
Hs Code.:

Synonyms:carbonic acid 8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl ester methyl ester

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Chemical Property of carbonic acid 8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl ester methyl ester

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Technology Process of carbonic acid 8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl ester methyl ester

There total 5 articles about carbonic acid 8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227164-98-8
[8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-yl]-methanol

: 79-22-1
methyl chloroformate

: 1227165-17-4
carbonic acid 8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl ester methyl ester

Guidance literature:: [8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-yl]-methanol; With sodium hydride; In tetrahydrofuran; oil; at -10 - 20 ℃; for 0.333333h;

methyl chloroformate; In tetrahydrofuran; oil; at 20 ℃; Inert atmosphere;

Reference yield:

: 180340-70-9
methyl 6-amino-5-bromopyridine-3-carboxylate

: 1227165-17-4
carbonic acid 8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl ester methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 6 h / 100 °C / Inert atmosphere

2.1: 3 h / 160 °C / Microwave irradiation

3.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere

3.2: 0.33 h / 20 °C / Cooling with ice; Acidic aqueous solution

3.3: pH 8 - 9

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / -10 - 20 °C

4.2: 20 °C / Inert atmosphere

With sodium hydride; diisobutylaluminium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; hexane; water; toluene; mineral oil;

Reference yield:

: 63503-60-6
3-chlorophenylboronic acid

: 1227165-17-4
carbonic acid 8-(3-chloro-phenyl)-2-methyl-imidazo[1,2-a]pyridin-6-ylmethyl ester methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 6 h / 100 °C / Inert atmosphere

2.1: 3 h / 160 °C / Microwave irradiation

3.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere

3.2: 0.33 h / 20 °C / Cooling with ice; Acidic aqueous solution

3.3: pH 8 - 9

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / -10 - 20 °C

4.2: 20 °C / Inert atmosphere

With sodium hydride; diisobutylaluminium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; hexane; water; toluene; mineral oil;