5-(4-isopropylsulfonylphenyl)-3-[3-[4-[(3R)-morpholin-3-yl]phenyl]isoxazol-5-yl]pyrazin-2-amine

Base Information

Chemical Name:5-(4-isopropylsulfonylphenyl)-3-[3-[4-[(3R)-morpholin-3-yl]phenyl]isoxazol-5-yl]pyrazin-2-amine
CAS No.:1429228-63-6
Molecular Formula:C₂₆H₂₇N₅O₄S
Molecular Weight:505.597
Hs Code.:

Synonyms:5-(4-isopropylsulfonylphenyl)-3-[3-[4-[(3R)-morpholin-3-yl]phenyl]isoxazol-5-yl]pyrazin-2-amine

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Chemical Property of 5-(4-isopropylsulfonylphenyl)-3-[3-[4-[(3R)-morpholin-3-yl]phenyl]isoxazol-5-yl]pyrazin-2-amine

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Technology Process of 5-(4-isopropylsulfonylphenyl)-3-[3-[4-[(3R)-morpholin-3-yl]phenyl]isoxazol-5-yl]pyrazin-2-amine

There total 15 articles about 5-(4-isopropylsulfonylphenyl)-3-[3-[4-[(3R)-morpholin-3-yl]phenyl]isoxazol-5-yl]pyrazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1429228-71-6
tert-butyl (3R)-3-{4-[5-(3-{bis[(tert-butoxy)carbonyl]amino}-6-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-yl)-1,2-oxazol-3-yl]phenyl}morpholine-4-carboxylate

: 1429228-63-6
5-(4-isopropylsulfonylphenyl)-3-[3-[4-[(3R)-morpholin-3-yl]phenyl]isoxazol-5-yl]pyrazin-2-amine

Guidance literature:: With hydrogenchloride; In methanol; dichloromethane; at 50 ℃;

Reference yield:

: 138713-44-7,74572-03-5
3-(-)-Phenyl morpholine

: 1429228-63-6
5-(4-isopropylsulfonylphenyl)-3-[3-[4-[(3R)-morpholin-3-yl]phenyl]isoxazol-5-yl]pyrazin-2-amine

Guidance literature:: Multi-step reaction with 10 steps

1: triethylamine / 0.5 h / 30 °C

2: [bis-(trifluoroacetoxy)iodo]benzene; iodine / dichloromethane / 0.5 h / 20 °C

3: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; carbon monoxide / methanol / 18 h / 65 °C / Cooling with ice

4: lithium borohydride / tetrahydrofuran-d8 / Reflux

5: manganese(IV) oxide / tetrahydrofuran / 20 °C

6: hydroxylamine / ethanol / 1 h / 20 °C

7: N-chloro-succinimide / N,N-dimethyl-d₆-formamide / 0.33 h / 55 °C

8: triethylamine / dichloromethane / 20 °C

9: sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / acetonitrile; water / 3 h / 25 °C / Inert atmosphere

10: hydrogenchloride / dichloromethane; methanol / 50 °C

With hydrogenchloride; manganese(IV) oxide; N-chloro-succinimide; lithium borohydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(tri-t-butylphosphine)palladium⁽⁰⁾; carbon monoxide; [bis-(trifluoroacetoxy)iodo]benzene; hydroxylamine; iodine; sodium carbonate; triethylamine; In tetrahydrofuran; methanol; tetrahydrofuran-d8; ethanol; dichloromethane; water; acetonitrile; N,N-dimethyl-d₆-formamide;

Reference yield:

: 1429228-65-8
(R)-tert-butyl 3-(4-iodophenyl)morpholine-4-carboxylate

: 1429228-63-6
5-(4-isopropylsulfonylphenyl)-3-[3-[4-[(3R)-morpholin-3-yl]phenyl]isoxazol-5-yl]pyrazin-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; carbon monoxide / methanol / 18 h / 65 °C / Cooling with ice

2: lithium borohydride / tetrahydrofuran-d8 / Reflux

3: manganese(IV) oxide / tetrahydrofuran / 20 °C

4: hydroxylamine / ethanol / 1 h / 20 °C

5: N-chloro-succinimide / N,N-dimethyl-d₆-formamide / 0.33 h / 55 °C

6: triethylamine / tetrahydrofuran / 2.5 h / 20 - 65 °C

7: hydrogenchloride / dichloromethane; methanol / 50 °C

With hydrogenchloride; manganese(IV) oxide; N-chloro-succinimide; lithium borohydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; carbon monoxide; hydroxylamine; triethylamine; In tetrahydrofuran; methanol; tetrahydrofuran-d8; ethanol; dichloromethane; N,N-dimethyl-d₆-formamide;