tert-butyl (3R)-3-{4-[5-(3-{bis[(tert-butoxy)carbonyl]amino}-6-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-yl)-1,2-oxazol-3-yl]phenyl}morpholine-4-carboxylate

Base Information

Chemical Name:tert-butyl (3R)-3-{4-[5-(3-{bis[(tert-butoxy)carbonyl]amino}-6-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-yl)-1,2-oxazol-3-yl]phenyl}morpholine-4-carboxylate
CAS No.:1429228-71-6
Molecular Formula:C₄₁H₅₁N₅O₁₀S
Molecular Weight:805.949
Hs Code.:

tert-butyl (3R)-3-{4-[5-(3-{bis[(tert-butoxy)carbonyl]amino}-6-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-yl)-1,2-oxazol-3-yl]phenyl}morpholine-4-carboxylate

Synonyms:tert-butyl (3R)-3-{4-[5-(3-{bis[(tert-butoxy)carbonyl]amino}-6-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-yl)-1,2-oxazol-3-yl]phenyl}morpholine-4-carboxylate

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Chemical Property of tert-butyl (3R)-3-{4-[5-(3-{bis[(tert-butoxy)carbonyl]amino}-6-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-yl)-1,2-oxazol-3-yl]phenyl}morpholine-4-carboxylate

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Technology Process of tert-butyl (3R)-3-{4-[5-(3-{bis[(tert-butoxy)carbonyl]amino}-6-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-yl)-1,2-oxazol-3-yl]phenyl}morpholine-4-carboxylate

There total 18 articles about tert-butyl (3R)-3-{4-[5-(3-{bis[(tert-butoxy)carbonyl]amino}-6-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-yl)-1,2-oxazol-3-yl]phenyl}morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 850567-98-5
4-(isopropylsulfonyl)phenylboronic acid

: 1429228-72-7
tert-butyl (3R)-3-[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-bromo-pyrazin-2-yl]isoxazol-3-yl]phenyl]morpholine-4-carboxylate

: 1429228-71-6
tert-butyl (3R)-3-{4-[5-(3-{bis[(tert-butoxy)carbonyl]amino}-6-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-yl)-1,2-oxazol-3-yl]phenyl}morpholine-4-carboxylate

Guidance literature:: With bis(tri-t-butylphosphine)palladium⁽⁰⁾; sodium carbonate; In water; acetonitrile; at 25 ℃; for 3h; Inert atmosphere;

Reference yield: 40.0%

: 1232423-98-1
tert-butyl N-(3-ethynyl-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-yl)N-tertbutoxycarbonyl-carbamate ?

: tert-butyl (3R)-3-{4-[chloro(hydroxyimino)methyl]phenyl}morpholine-4-carboxylate

: 1429228-71-6
tert-butyl (3R)-3-{4-[5-(3-{bis[(tert-butoxy)carbonyl]amino}-6-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-yl)-1,2-oxazol-3-yl]phenyl}morpholine-4-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 - 65 ℃; for 2.5h;

Reference yield:

: 138713-44-7,74572-03-5
3-(-)-Phenyl morpholine

: 1429228-71-6
tert-butyl (3R)-3-{4-[5-(3-{bis[(tert-butoxy)carbonyl]amino}-6-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-yl)-1,2-oxazol-3-yl]phenyl}morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / 0.5 h / 30 °C

2: [bis-(trifluoroacetoxy)iodo]benzene; iodine / dichloromethane / 0.5 h / 20 °C

3: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; carbon monoxide / methanol / 18 h / 65 °C / Cooling with ice

4: lithium borohydride / tetrahydrofuran-d8 / Reflux

5: manganese(IV) oxide / tetrahydrofuran / 20 °C

6: hydroxylamine / ethanol / 1 h / 20 °C

7: N-chloro-succinimide / N,N-dimethyl-d₆-formamide / 0.33 h / 55 °C

8: triethylamine / tetrahydrofuran / 2.5 h / 20 - 65 °C

With manganese(IV) oxide; N-chloro-succinimide; lithium borohydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; carbon monoxide; [bis-(trifluoroacetoxy)iodo]benzene; hydroxylamine; iodine; triethylamine; In tetrahydrofuran; methanol; tetrahydrofuran-d8; ethanol; dichloromethane; N,N-dimethyl-d₆-formamide;