3β-(4-methylphenyl)tropane-2β-N-4'-fluorophenacylcarboxamide ethylene ketal

Base Information

Chemical Name:3β-(4-methylphenyl)tropane-2β-N-4'-fluorophenacylcarboxamide ethylene ketal
CAS No.:947594-90-3
Molecular Formula:C₂₆H₃₁FN₂O₃
Molecular Weight:438.542
Hs Code.:

Synonyms:3β-(4-methylphenyl)tropane-2β-N-4'-fluorophenacylcarboxamide ethylene ketal

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Chemical Property of 3β-(4-methylphenyl)tropane-2β-N-4'-fluorophenacylcarboxamide ethylene ketal

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Technology Process of 3β-(4-methylphenyl)tropane-2β-N-4'-fluorophenacylcarboxamide ethylene ketal

There total 4 articles about 3β-(4-methylphenyl)tropane-2β-N-4'-fluorophenacylcarboxamide ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 3239-85-8
4-fluorophenacylamine ethylene ketal

: 141807-59-2
8-methyl-3S-p-tolyl-8-azabicyclo[3.2.1]octane-2S-carboxylic acid

: 947594-90-3
3β-(4-methylphenyl)tropane-2β-N-4'-fluorophenacylcarboxamide ethylene ketal

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 25 ℃; for 48h;
DOI:10.1021/jm0703035

Reference yield:

: 947594-45-8
4-fluorophenacyl azide ethylene ketal

: 947594-90-3
3β-(4-methylphenyl)tropane-2β-N-4'-fluorophenacylcarboxamide ethylene ketal

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine / tetrahydrofuran

1.2: 73 percent / water / tetrahydrofuran

2.1: 78 percent / 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 48 h / 25 °C

With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Staudinger reaction;
DOI:10.1021/jm0703035

Reference yield:

: 118887-70-0
2-azido-1-(4-fluoro-phenyl)-ethanone

: 947594-90-3
3β-(4-methylphenyl)tropane-2β-N-4'-fluorophenacylcarboxamide ethylene ketal

Guidance literature:: Multi-step reaction with 3 steps

1.1: 87 percent / boron trifluoride etherate / CH₂Cl₂ / 20 °C

2.1: triphenylphosphine / tetrahydrofuran

2.2: 73 percent / water / tetrahydrofuran

3.1: 78 percent / 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 48 h / 25 °C

With 1-hydroxy-7-aza-benzotriazole; boron trifluoride diethyl etherate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2.1: Staudinger reaction;
DOI:10.1021/jm0703035