[(R)-3'-[(tert-butyldimethylsilyl)oxy]-4'-methylene-cyclohexylidene] acetic acid methyl ester

Base Information

Chemical Name:[(R)-3'-[(tert-butyldimethylsilyl)oxy]-4'-methylene-cyclohexylidene] acetic acid methyl ester
CAS No.:1279708-92-7
Molecular Formula:C₁₆H₂₈O₃Si
Molecular Weight:296.482
Hs Code.:

Synonyms:[(R)-3'-[(tert-butyldimethylsilyl)oxy]-4'-methylene-cyclohexylidene] acetic acid methyl ester

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Chemical Property of [(R)-3'-[(tert-butyldimethylsilyl)oxy]-4'-methylene-cyclohexylidene] acetic acid methyl ester

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Technology Process of [(R)-3'-[(tert-butyldimethylsilyl)oxy]-4'-methylene-cyclohexylidene] acetic acid methyl ester

There total 10 articles about [(R)-3'-[(tert-butyldimethylsilyl)oxy]-4'-methylene-cyclohexylidene] acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1246364-48-6
(R)-3-[(tert-Butyldimethylsilyl)oxy]-4-methylene-cyclohexanone

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 1279708-92-7
[(R)-3'-[(tert-butyldimethylsilyl)oxy]-4'-methylene-cyclohexylidene] acetic acid methyl ester

Guidance literature:: In benzene; for 15h; Reflux;

Reference yield:

: 665-27-0
1,5-quinide

: 1279708-92-7
[(R)-3'-[(tert-butyldimethylsilyl)oxy]-4'-methylene-cyclohexylidene] acetic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetonitrile / 6 h / 20 °C

2.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / benzene; tetrahydrofuran / 3 h / Reflux

3.1: dipyridinium dichromate / acetonitrile / 5 h / 20 °C / Molecular sieve

4.1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C

4.2: 2 h / 20 °C

5.1: 48 h / 20 °C / Molecular sieve

5.2: -40 - 20 °C

6.1: diisobutylaluminium hydride / dichloromethane / 3 h / -70 - -30 °C

7.1: sodium periodate / water; methanol / 1 h / 0 °C

8.1: benzene / 15 h / Reflux

With sodium periodate; dipyridinium dichromate; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; tri-n-butyl-tin hydride; diisobutylaluminium hydride; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; benzene; 4.1: Wittig Reaction / 8.1: Wittig Reaction;

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 1279708-92-7
[(R)-3'-[(tert-butyldimethylsilyl)oxy]-4'-methylene-cyclohexylidene] acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 48 h / 20 °C / Molecular sieve

1.2: -40 - 20 °C

2.1: diisobutylaluminium hydride / dichloromethane / 3 h / -70 - -30 °C

3.1: sodium periodate / water; methanol / 1 h / 0 °C

4.1: benzene / 15 h / Reflux

With sodium periodate; diisobutylaluminium hydride; In methanol; dichloromethane; water; benzene; 4.1: Wittig Reaction;