[(E)-[(3'R)-[(tert-butyldimethylsilyl)oxy]-4'-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

Base Information

Chemical Name:[(E)-[(3'R)-[(tert-butyldimethylsilyl)oxy]-4'-methylenecyclohexylidene]ethyl]diphenylphosphine oxide
CAS No.:1246364-54-4
Molecular Formula:C₂₇H₃₇O₂PSi
Molecular Weight:452.649
Hs Code.:

Synonyms:[(E)-[(3'R)-[(tert-butyldimethylsilyl)oxy]-4'-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

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Chemical Property of [(E)-[(3'R)-[(tert-butyldimethylsilyl)oxy]-4'-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

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Technology Process of [(E)-[(3'R)-[(tert-butyldimethylsilyl)oxy]-4'-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

There total 10 articles about [(E)-[(3'R)-[(tert-butyldimethylsilyl)oxy]-4'-methylenecyclohexylidene]ethyl]diphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1246364-52-2
(E)-2-[(R)-3'-[(tert-butyldimethylsilyl)oxy]-4'-methylene-cyclohexylidene]ethanol

: 829-85-6
diphenylphosphane

: 1246364-54-4
[(E)-[(3'R)-[(tert-butyldimethylsilyl)oxy]-4'-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

Guidance literature:: (E)-2-[(R)-3'-[(tert-butyldimethylsilyl)oxy]-4'-methylene-cyclohexylidene]ethanol; With n-butyllithium; p-toluenesulfonyl chloride; In tetrahydrofuran; hexane; at 0 ℃; Inert atmosphere;

diphenylphosphane; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; Inert atmosphere;

With dihydrogen peroxide; In dichloromethane; water; at 0 ℃; for 1h;

Reference yield:

: 1279708-92-7
[(R)-3'-[(tert-butyldimethylsilyl)oxy]-4'-methylene-cyclohexylidene] acetic acid methyl ester

: 1246364-54-4
[(E)-[(3'R)-[(tert-butyldimethylsilyl)oxy]-4'-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

Guidance literature:: Multi-step reaction with 4 steps

1: diisobutylaluminium hydride / dichloromethane

2: n-butyllithium / tetrahydrofuran

3: n-butyllithium / tetrahydrofuran

4: dihydrogen peroxide / dichloromethane; water

With n-butyllithium; dihydrogen peroxide; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.jsbmb.2010.03.063

Reference yield:

: 1246364-52-2
(E)-2-[(R)-3'-[(tert-butyldimethylsilyl)oxy]-4'-methylene-cyclohexylidene]ethanol

: 1246364-54-4
[(E)-[(3'R)-[(tert-butyldimethylsilyl)oxy]-4'-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran

2: n-butyllithium / tetrahydrofuran

3: dihydrogen peroxide / dichloromethane; water

With n-butyllithium; dihydrogen peroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.jsbmb.2010.03.063