(S)-2-Benzyloxycarbonylamino-3-(4-benzyloxy-phenyl)-propionic acid benzotriazol-1-yl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-3-(4-benzyloxy-phenyl)-propionic acid benzotriazol-1-yl ester
CAS No.:126814-53-7
Molecular Formula:C₃₀H₂₆N₄O₅
Molecular Weight:522.56
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-3-(4-benzyloxy-phenyl)-propionic acid benzotriazol-1-yl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-3-(4-benzyloxy-phenyl)-propionic acid benzotriazol-1-yl ester

Chemical Property:

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Technology Process of (S)-2-Benzyloxycarbonylamino-3-(4-benzyloxy-phenyl)-propionic acid benzotriazol-1-yl ester

There total 1 articles about (S)-2-Benzyloxycarbonylamino-3-(4-benzyloxy-phenyl)-propionic acid benzotriazol-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86827-18-1,92455-53-3,16677-29-5
N-benzyloxycarbonyl-O-benzyl-L-tyrosine

: 2592-95-2
benzotriazol-1-ol

: 126814-53-7
(S)-2-Benzyloxycarbonylamino-3-(4-benzyloxy-phenyl)-propionic acid benzotriazol-1-yl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

Reference yield:

: 126814-53-7
(S)-2-Benzyloxycarbonylamino-3-(4-benzyloxy-phenyl)-propionic acid benzotriazol-1-yl ester

: 113247-65-7
L-tyrosyl2,L-Ser⁵-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-L-serylglycyl-L-phenylalanyl-L-serine>

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-di-isopropylethylamine / tetrahydrofuran / 0 deg C --> room temp., 2 h

2: 76 percent / TFA / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 31 percent / pyridine / 144 h

4: 65 percent / H₂ / Pd/C / methanol; CH₂Cl₂

With hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane;

Reference yield:

: 126814-53-7
(S)-2-Benzyloxycarbonylamino-3-(4-benzyloxy-phenyl)-propionic acid benzotriazol-1-yl ester

: 113247-66-8
L-tyrosyl2,L-Ser⁵-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-D-serylglycyl-L-phenylalanyl-L-serine>

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-di-isopropylethylamine / tetrahydrofuran / 0 deg C --> room temp., 2 h

2: 70 percent / TFA / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 86 percent / pyridine / 144 h

4: 31 percent / H₂ / Pd/C / dimethylformamide / 4 h

With hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide;