1-(4-methoxybenzenesulfonyl)-3-(S)-(5-phenylpentyl)aziridine-2-(R)-carboxylic acid

Base Information

Chemical Name:1-(4-methoxybenzenesulfonyl)-3-(S)-(5-phenylpentyl)aziridine-2-(R)-carboxylic acid
CAS No.:370064-92-9
Molecular Formula:C₂₁H₂₅NO₅S
Molecular Weight:403.499
Hs Code.:

Synonyms:1-(4-methoxybenzenesulfonyl)-3-(S)-(5-phenylpentyl)aziridine-2-(R)-carboxylic acid

Suppliers and Price of 1-(4-methoxybenzenesulfonyl)-3-(S)-(5-phenylpentyl)aziridine-2-(R)-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(4-methoxybenzenesulfonyl)-3-(S)-(5-phenylpentyl)aziridine-2-(R)-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(4-methoxybenzenesulfonyl)-3-(S)-(5-phenylpentyl)aziridine-2-(R)-carboxylic acid

There total 8 articles about 1-(4-methoxybenzenesulfonyl)-3-(S)-(5-phenylpentyl)aziridine-2-(R)-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 370064-90-7
1-(4-methoxybenzenesulfonyl)-3-(S)-(5-phenylpentyl)aziridine-2-(R)-carboxylic acid benzyl ester

: 370064-92-9
1-(4-methoxybenzenesulfonyl)-3-(S)-(5-phenylpentyl)aziridine-2-(R)-carboxylic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 16h; under 760 Torr;
DOI:10.1016/S0040-4020(01)00641-X

Reference yield:

: 144809-41-6
(E)-8-phenyloct-2-enoic acid methyl ester

: 370064-92-9
1-(4-methoxybenzenesulfonyl)-3-(S)-(5-phenylpentyl)aziridine-2-(R)-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: 96 percent / LiOH / H₂O; tetrahydrofuran / 48 h / 45 °C

2.1: oxalyl chloride / dimethylformamide; CH₂Cl₂ / 3.5 h / 0 - 20 °C

3.1: 1.40 g / n-BuLi / tetrahydrofuran / 1 h / -78 °C

4.1: 93 percent / Bu₂BOTf / CH₂Cl₂ / 1 h / -78 °C

5.1: Me₂AlCl / CH₂Cl₂ / 0.33 h / 0 °C

5.2: 94 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

6.1: 93 percent / n-BBuLi / tetrahydrofuran / 2 h / 0 °C

7.1: 91 percent / Et₃N; BnOH / CH₂Cl₂ / 48 h / 20 °C

8.1: 86 percent / H₂ / 10 percent Pd/C / ethanol / 16 h / 760 Torr

With lithium hydroxide; n-butyllithium; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; hydrogen; dimethylaluminum chloride; triethylamine; benzyl alcohol; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00641-X

Reference yield:

: (E)-8-phenyloct-2-enoic acid chloride

: 370064-92-9
1-(4-methoxybenzenesulfonyl)-3-(S)-(5-phenylpentyl)aziridine-2-(R)-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1.40 g / n-BuLi / tetrahydrofuran / 1 h / -78 °C

2.1: 93 percent / Bu₂BOTf / CH₂Cl₂ / 1 h / -78 °C

3.1: Me₂AlCl / CH₂Cl₂ / 0.33 h / 0 °C

3.2: 94 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

4.1: 93 percent / n-BBuLi / tetrahydrofuran / 2 h / 0 °C

5.1: 91 percent / Et₃N; BnOH / CH₂Cl₂ / 48 h / 20 °C

6.1: 86 percent / H₂ / 10 percent Pd/C / ethanol / 16 h / 760 Torr

With n-butyllithium; di-n-butylboryl trifluoromethanesulfonate; hydrogen; dimethylaluminum chloride; triethylamine; benzyl alcohol; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)00641-X