144809-41-6Relevant academic research and scientific papers
Design and synthesis of MMP inhibitors using N-arylsulfonylaziridine hydroxamic acids as constrained scaffolds
Hanessian, Stephen,Moitessier, Nicolas,Cantin, Louis-David
, p. 6885 - 6900 (2007/10/03)
The synthesis of cis- and trans-aziridine hydroxamic acid derivatives as MMP inhibitors is described using enantio- and diastereoselective methods for the formation of trisubstituted aziridines. Their preliminary inhibitory activity is reported and discus
Copper-catalyzed allylic alkylations of alkylzirconium intermediates
Venanzi, Luigi M.,Lehmann, Roman,Keil, Robert,Lipshutz, Bruce H.
, p. 5857 - 5860 (2007/10/02)
Hydrozirconation of olefins followed by exposure of the resulting alkylzirconium species to catalytic CuCN in the presence of activated halides or phosphonates gives rise to products of aklkylation in good yields under mild conditions.
