7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-7-deaza-2'-deoxyadenosine-5'-triphosphate

Base Information

Chemical Name:7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-7-deaza-2'-deoxyadenosine-5'-triphosphate
CAS No.:1372854-54-0
Molecular Formula:C₂₄H₃₄N₅O₁₆P₃
Molecular Weight:741.479
Hs Code.:

Synonyms:7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-7-deaza-2'-deoxyadenosine-5'-triphosphate

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Chemical Property of 7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-7-deaza-2'-deoxyadenosine-5'-triphosphate

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Technology Process of 7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-7-deaza-2'-deoxyadenosine-5'-triphosphate

There total 14 articles about 7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-7-deaza-2'-deoxyadenosine-5'-triphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372854-53-9
7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2’-deoxyadenosine

: 1372854-54-0
7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-7-deaza-2'-deoxyadenosine-5'-triphosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate / 7.5 h / 0 °C / Inert atmosphere

2.1: tributyl-amine; bis(tri-n-butylammonium) pyrophosphate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 1 h / 20 °C / pH 7.5 / Inert atmosphere; aq. buffer

With tributyl-amine; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; bis(tri-n-butylammonium) pyrophosphate; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1002/anie.201106516

Reference yield:

: C₂₆H₃₆N₅O₁₀P

: 1372854-54-0
7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-7-deaza-2'-deoxyadenosine-5'-triphosphate

Guidance literature:: C₂₆H₃₆N₅O₁₀P; With tributyl-amine; bis(tri-n-butylammonium) pyrophosphate; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

In N,N-dimethyl-formamide; at 20 ℃; for 1h; pH=7.5; Inert atmosphere; aq. buffer;
DOI:10.1002/anie.201106516

Reference yield:

: 1372854-34-6
(R/S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-1-propanol

: 1372854-54-0
7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-7-deaza-2'-deoxyadenosine-5'-triphosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 0.75 h / 110 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3.1: ammonia / 1,4-dioxane; methanol / 24 h / 100 °C

4.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate / 7.5 h / 0 °C / Inert atmosphere

5.1: tributyl-amine; bis(tri-n-butylammonium) pyrophosphate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

5.2: 1 h / 20 °C / pH 7.5 / Inert atmosphere; aq. buffer

With tributyl-amine; tetrabutyl ammonium fluoride; ammonia; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; bis(tri-n-butylammonium) pyrophosphate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1002/anie.201106516