7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2’-deoxyadenosine

Base Information

Chemical Name:7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2’-deoxyadenosine
CAS No.:1372854-53-9
Molecular Formula:C₂₄H₃₁N₅O₇
Molecular Weight:501.539
Hs Code.:

Synonyms:7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2’-deoxyadenosine

Suppliers and Price of 7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2’-deoxyadenosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of 7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2’-deoxyadenosine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2’-deoxyadenosine

There total 12 articles about 7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2’-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1372854-52-8
6-chloro-9-[β-D-2‘-deoxyribofuranosyl]-7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-propyloxy]methyl-7-deazapurine

: 1372854-53-9
7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2’-deoxyadenosine

Guidance literature:: With ammonia; In 1,4-dioxane; methanol; at 100 ℃; for 24h;
DOI:10.1002/anie.201106516

Reference yield:

: 1372854-34-6
(R/S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethyl-1-propanol

: 1372854-53-9
7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2’-deoxyadenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 0.75 h / 110 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: ammonia / 1,4-dioxane; methanol / 24 h / 100 °C

With tetrabutyl ammonium fluoride; ammonia; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1002/anie.201106516

Reference yield:

: 1200462-07-2
9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2‘-deoxyribofuranosyl]-6-chloro-7-iodo-7-deazapurine

: 1372854-53-9
7-[(S)-1-(5-methoxy-2-nitrophenyl)-2,2-dimethylpropyloxy]methyl-7-deaza-2’-deoxyadenosine

Guidance literature:: Multi-step reaction with 6 steps

1: bis(benzonitrile)palladium(II) dichloride; triethylamine / 1,4-dioxane / 48 h / 50 °C

2: lithium borohydride / tetrahydrofuran; methanol / 0.92 h / 20 °C / Reflux

3: dmap; p-toluenesulfonyl chloride / dichloromethane / 18 h / 20 °C

4: 0.75 h / 110 °C / Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

6: ammonia / 1,4-dioxane; methanol / 24 h / 100 °C

With dmap; bis(benzonitrile)palladium(II) dichloride; lithium borohydride; tetrabutyl ammonium fluoride; ammonia; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1002/anie.201106516