5-(4-chloro-3-fluorobenzyl)-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

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Chemical Name:5-(4-chloro-3-fluorobenzyl)-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile
CAS No.:1616371-97-1
Molecular Formula:C₂₇H₂₅ClFN₅
Molecular Weight:473.98
Hs Code.:

Synonyms:5-(4-chloro-3-fluorobenzyl)-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

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Chemical Property of 5-(4-chloro-3-fluorobenzyl)-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

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Technology Process of 5-(4-chloro-3-fluorobenzyl)-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

There total 12 articles about 5-(4-chloro-3-fluorobenzyl)-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616371-96-0
4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

: 206362-80-3
4-(bromomethyl)-1-chloro-2-fluorobenzene

: 1616371-97-1
5-(4-chloro-3-fluorobenzyl)-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl acetamide; at 25 ℃; for 72h;

Reference yield:

: 1338377-74-4
(S)-N-[(1E)-cyclobutylmethylidene]-2-methylpropane-2-sulfinamide

: 1616371-97-1
5-(4-chloro-3-fluorobenzyl)-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran; diethyl ether / 6 h / -78 - -40 °C / Inert atmosphere

2: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 0 - 25 °C

3: N-ethyl-N,N-diisopropylamine / ethanol / 72 h / 70 °C

4: XPhos; bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 2 h / 60 - 120 °C / Inert atmosphere; Sealed tube

5: potassium carbonate / N,N-dimethyl acetamide / 72 h / 25 °C

With hydrogenchloride; bis(η3-allyl-μ-chloropalladium(II)); potassium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; N,N-dimethyl acetamide;

Reference yield:

: 1616372-27-0
(S)-N-[(1R)-1-cyclobutylethyl]-2-methylpropane-2-sulfinamide

: 1616371-97-1
5-(4-chloro-3-fluorobenzyl)-4-{[(1R)-1-cyclobutylethyl]amino}-6-(3-methylphenyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 0 - 25 °C

2: N-ethyl-N,N-diisopropylamine / ethanol / 72 h / 70 °C

3: XPhos; bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 2 h / 60 - 120 °C / Inert atmosphere; Sealed tube

4: potassium carbonate / N,N-dimethyl acetamide / 72 h / 25 °C

With hydrogenchloride; bis(η3-allyl-μ-chloropalladium(II)); potassium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl acetamide;