206362-80-3

Basic information

• Product Name: 4-CHLORO-3-FLUOROBENZYL BROMIDE
• Synonyms: 4-Chloro-3-fluorobenzyl bromide 97%;4-Chloro-3-fluorobenzylbromide97%;4-(bromomethyl)-1-chloro-2-fluorobenzene;REF DUPL: 4-Chloro-3-fluorobenzyl bromide;alpha-Bromo-4-chloro-3-fluorotoluene 1-(Bromomethyl)-4-chloro-3-fluorobenzene;4-(Bromomethyl)-1-chloro-2-fluorobenzene, alpha-Bromo-4-chloro-3-fluorotoluene
• CAS NO: 206362-80-3
• Molecular Formula: C₇H₅BrClF
• Molecular Weight: 223.48
• Mol File: 206362-80-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 30-33℃
• Boiling Point: 227.1 °C at 760 mmHg
• Flash Point: 91.1 °C
• Appearance: /
• Density: 1.654 g/cm³
• Vapor Pressure: 0.119mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• Sensitive: Lachrymatory
• CAS DataBase Reference: 4-CHLORO-3-FLUOROBENZYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-FLUOROBENZYL BROMIDE(206362-80-3)
• EPA Substance Registry System: 4-CHLORO-3-FLUOROBENZYL BROMIDE(206362-80-3)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• HazardClass: CORROSIVE
• PackingGroup: Ⅱ
• Hazardous Substances Data: 206362-80-3(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H5BrClF/c8-4-5-1-2-6(9)7(10)3-5/h1-3H,4H2

Upstream product

• 106-95-6 allyl bromide 
• 206362-77-8 3-Chloro-4-fluorothiophene-1,1-dioxide 
• 106-96-7 propargyl bromide 
• 202925-10-8 (4-chloro-3-fluorophenyl)methanol 

Downstream Products

• 251570-03-3 2-(4-chloro-3-fluorophenyl)acetonitrile 
• 1240660-23-4 3-acetyl-1-(4-chloro-3-fluorobenzyl)-4-methoxy-1H-indole 
• 174701-71-4 (4-chloro-3-fluorobenzyl)-triphenylphosphonium bromide 
• 849766-53-6 tert-butyl 4-(4-chloro-3-fluorobenzyl)piperidine-1-carboxylate 

Relevant articles and documents

SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR

Disclosed are a 2-aminopyridine derivative having protein kinase inhibition activity, a preparation method and a pharmaceutical composition thereof Also disclosed are uses of the compounds and the pharmaceutical compositions thereof in the preparation of drugs for treating and/or preventing protein kinase-related diseases.

3-Chloro-4-fluorothiophene-1,1-dioxide. A new synthetically useful fluorodiene

Simple, three step synthesis of a new fluorine containing diene, 3-chloro-4-fluorothiophene-1,1 -dioxide (4), from commercially available 3-sulpholene (1) has been developed. The synthetic value of compound 4 as a Diels - Alder diene has been demonstrated by its reactions with various type of dienophiles: acetylenes, alkenes, furans, quinone and anthracene. The reactions proceed with high regioselectivity to give good yields of 3-fluoro-4-chloro substituted aromatics or cyclic chlorofluorodienes. In reactions with alkenes, immediate aromatisation often occurs. In some instances, when reacted with a diene, compound 4 behaves as a dienophile.