206362-80-3

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H5BrClF/c8-4-5-1-2-6(9)7(10)3-5/h1-3H,4H2

Upstream product

• 202925-10-8 (4-chloro-3-fluorophenyl)methanol 
• 106-96-7 propargyl bromide 
• 206362-77-8 3-Chloro-4-fluorothiophene-1,1-dioxide 
• 106-95-6 allyl bromide 

Downstream Products

• 1240660-23-4 3-acetyl-1-(4-chloro-3-fluorobenzyl)-4-methoxy-1H-indole 

Relevant academic research and scientific papers

SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR

Disclosed are a 2-aminopyridine derivative having protein kinase inhibition activity, a preparation method and a pharmaceutical composition thereof Also disclosed are uses of the compounds and the pharmaceutical compositions thereof in the preparation of drugs for treating and/or preventing protein kinase-related diseases.

Indole derivatives and their use as MCP-1 antagonist

A compound of formula (1) wherein R1 is hydrogen, halo or methoxy, R2 is hydrogen, halo, methyl, ethyl or methoxy; R3 is carboxy, tetrazolyl, or —CONHSO2R4where R4is methyl, ethyl, phenyl, 2,5-dimethylisoxazolyl or trifluoromethyl; T is —CH2— or —SO2—; and ring A is 3-chlorophenyl, 4-chlorophenyl, 3-trifluoromethylphenyl, 3,4-dichlorophenyl, 3,4-difluorophenyl, 3-fluoro-4-chlorophenyl, 3-chloro-4-fluorophenyl or 2,3-dichloropyrid-5-yl; or a pharmaceutically acceptable salt or prodrug thereof, as well as pharmaceutical compositions containing them are described and claimed. These compounds and compositions are useful in the treatment of disease mediated by monocyte chemoattractant protein-1 or RANTES (Regulated Upon Activation, Normal T-cell Expressed and Secreted), such as inflammatory disease.

3-Chloro-4-fluorothiophene-1,1-dioxide. A new synthetically useful fluorodiene

Simple, three step synthesis of a new fluorine containing diene, 3-chloro-4-fluorothiophene-1,1 -dioxide (4), from commercially available 3-sulpholene (1) has been developed. The synthetic value of compound 4 as a Diels - Alder diene has been demonstrated by its reactions with various type of dienophiles: acetylenes, alkenes, furans, quinone and anthracene. The reactions proceed with high regioselectivity to give good yields of 3-fluoro-4-chloro substituted aromatics or cyclic chlorofluorodienes. In reactions with alkenes, immediate aromatisation often occurs. In some instances, when reacted with a diene, compound 4 behaves as a dienophile.