206362-80-3Relevant articles and documents
SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR
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Paragraph 0185, (2015/12/19)
Disclosed are a 2-aminopyridine derivative having protein kinase inhibition activity, a preparation method and a pharmaceutical composition thereof Also disclosed are uses of the compounds and the pharmaceutical compositions thereof in the preparation of drugs for treating and/or preventing protein kinase-related diseases.
3-Chloro-4-fluorothiophene-1,1-dioxide. A new synthetically useful fluorodiene
Dmowski, Wojciech,Manko, Vladimir A.,Nowak, Ireneusz
, p. 143 - 151 (2007/10/03)
Simple, three step synthesis of a new fluorine containing diene, 3-chloro-4-fluorothiophene-1,1 -dioxide (4), from commercially available 3-sulpholene (1) has been developed. The synthetic value of compound 4 as a Diels - Alder diene has been demonstrated by its reactions with various type of dienophiles: acetylenes, alkenes, furans, quinone and anthracene. The reactions proceed with high regioselectivity to give good yields of 3-fluoro-4-chloro substituted aromatics or cyclic chlorofluorodienes. In reactions with alkenes, immediate aromatisation often occurs. In some instances, when reacted with a diene, compound 4 behaves as a dienophile.